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Abstract：
UNASSIGNED: Human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) is an evolving and growing disease, especially in developing countries. However, the clinical characteristics of HPV-associated HNSCC in regard to HPV infection rates, patient features, and prognosis are under-reported in the Asian population.
UNASSIGNED: In this study, we retrospectively enrolled a 400-case cohort of HNSCC with p16 immunochemistry and analyzed with long-term follow-up. We investigate the current HPV prevalence of HNSCC, unique HPV-associated patient clinical characteristics, and patient prognosis in the southern China population.
UNASSIGNED: HPV infection exhibited a 15% prevalence in all HNSCC cases, notably higher in oropharyngeal cases (30.7%), followed by oral cavity (11.8%), laryngeal (10.1%), and hypopharyngeal (2.5%). HPV status, gender, old age, and location of tumor were significantly associated with the patient\'s survival. Tonsil invasion was found more frequent in HPV-positive oropharyngeal HNSCC than in HPV-negative cases. HPV-associated HNSCC patients tend to possess stronger tobacco and alcohol habits, which were correlated to poor survival. HPV status\'s correlation with gender, age, and anatomical location is associated intricately with patient survival. The secondary primary tumor rate was found higher within the HPV-negative group, compared to the HPV-positive group (9.12% versus 1.67%).
UNASSIGNED: Our study provided a current picture of HPV-associated HNSCC in the southern China population and elaborated the understanding of key factors that correlate to HNSCC prognosis. Our findings indicated a strong susceptibility of HPV-associated oropharyngeal HNSCC in the tonsil and the difference in secondary primary tumor rates associated with HPV status.
HPV in head and neck cancer In this study, we retrospectively enrolled a 400-case cohort of HNSCC with p16 immunochemistry and analyzed with long-term follow-up. We investigate the current HPV prevalence of HNSCC, unique HPV-associated patient characteristics, along with patient prognosis in southern China population. Our findings indicated a strong susceptibility of HPV-associated oropharyngeal HNSCC in tonsil and difference of secondary primary tumor associated with HPV status. Our study provided a current picture of HPV-associated HNSCC in southern China population and elaborated the understanding of key factors that correlate to HNSCC prognosis.
UNASSIGNED: In this study, we retrospectively enrolled a 400-case cohort of HNSCC with p16 immunochemistry and analyzed with long-term follow-up. We investigate the current HPV prevalence of HNSCC, unique HPV-associated patient clinical characteristics, and patient prognosis in the southern China population.
UNASSIGNED: HPV infection exhibited a 15% prevalence in all HNSCC cases, notably higher in oropharyngeal cases (30.7%), followed by oral cavity (11.8%), laryngeal (10.1%), and hypopharyngeal (2.5%). HPV status, gender, old age, and location of tumor were significantly associated with the patient\'s survival. Tonsil invasion was found more frequent in HPV-positive oropharyngeal HNSCC than in HPV-negative cases. HPV-associated HNSCC patients tend to possess stronger tobacco and alcohol habits, which were correlated to poor survival. HPV status\'s correlation with gender, age, and anatomical location is associated intricately with patient survival. The secondary primary tumor rate was found higher within the HPV-negative group, compared to the HPV-positive group (9.12% versus 1.67%).
UNASSIGNED: Our study provided a current picture of HPV-associated HNSCC in the southern China population and elaborated the understanding of key factors that correlate to HNSCC prognosis. Our findings indicated a strong susceptibility of HPV-associated oropharyngeal HNSCC in the tonsil and the difference in secondary primary tumor rates associated with HPV status.
HPV in head and neck cancer In this study, we retrospectively enrolled a 400-case cohort of HNSCC with p16 immunochemistry and analyzed with long-term follow-up. We investigate the current HPV prevalence of HNSCC, unique HPV-associated patient characteristics, along with patient prognosis in southern China population. Our findings indicated a strong susceptibility of HPV-associated oropharyngeal HNSCC in tonsil and difference of secondary primary tumor associated with HPV status. Our study provided a current picture of HPV-associated HNSCC in southern China population and elaborated the understanding of key factors that correlate to HNSCC prognosis.
摘要：
人乳头瘤病毒（HPV）相关的头颈部鳞状细胞癌（HNSCC）是一种不断发展的疾病，尤其是在发展中国家。然而,HPV相关HNSCC在HPV感染率方面的临床特征，患者特征,亚洲人群的预后报道不足。
■在这项研究中，我们采用p16免疫化学方法回顾性纳入了400例HNSCC队列,并进行了长期随访分析.我们调查了HNSCC的当前HPV患病率，独特的HPV相关患者临床特征，和中国南方人群的患者预后。
■HPV感染在所有HNSCC病例中的患病率为15％，口咽病例明显更高(30.7%)，其次是口腔(11.8%)，喉部（10.1%），下咽（2.5%）。HPV状态，性别,老年,肿瘤的位置与患者的生存率显著相关。与HPV阴性病例相比，HPV阳性口咽HNSCC的扁桃体侵袭更频繁。HPV相关的HNSCC患者倾向于拥有更强的烟草和酒精习惯，这与低生存率有关。HPV状态与性别的相关性，年龄,解剖位置与患者生存密切相关。在HPV阴性组中发现继发性原发肿瘤率较高，与HPV阳性组相比（9.12%对1.67%）。
■我们的研究提供了中国南方人群中与HPV相关的HNSCC的最新情况，并阐述了对与HNSCC预后相关的关键因素的理解。我们的发现表明，扁桃体中HPV相关口咽HNSCC的易感性很强，并且与HPV状态相关的继发性原发性肿瘤发生率存在差异。
头颈部肿瘤中的HPV在本研究中,我们采用p16免疫化学方法回顾性纳入了400例HNSCC队列,并进行了长期随访分析.我们调查了HNSCC的当前HPV患病率，独特的HPV相关患者特征，以及中国南方人群的患者预后。我们的发现表明，扁桃体中HPV相关口咽HNSCC的易感性很强，并且与HPV状态相关的继发性原发性肿瘤存在差异。我们的研究提供了中国南方人群中HPV相关HNSCC的最新情况，并阐述了与HNSCC预后相关的关键因素的理解。
■在这项研究中，我们采用p16免疫化学方法回顾性纳入了400例HNSCC队列,并进行了长期随访分析.我们调查了HNSCC的当前HPV患病率，独特的HPV相关患者临床特征，和中国南方人群的患者预后。
■HPV感染在所有HNSCC病例中的患病率为15％，口咽病例明显更高(30.7%)，其次是口腔(11.8%)，喉部（10.1%），下咽（2.5%）。HPV状态，性别,老年,肿瘤的位置与患者的生存率显著相关。与HPV阴性病例相比，HPV阳性口咽HNSCC的扁桃体侵袭更频繁。HPV相关的HNSCC患者倾向于拥有更强的烟草和酒精习惯，这与低生存率有关。HPV状态与性别的相关性，年龄,解剖位置与患者生存密切相关。在HPV阴性组中发现继发性原发肿瘤率较高，与HPV阳性组相比（9.12%对1.67%）。
■我们的研究提供了中国南方人群中与HPV相关的HNSCC的最新情况，并阐述了对与HNSCC预后相关的关键因素的理解。我们的发现表明，扁桃体中HPV相关口咽HNSCC的易感性很强，并且与HPV状态相关的继发性原发性肿瘤发生率存在差异。
头颈部肿瘤中的HPV在本研究中,我们采用p16免疫化学方法回顾性纳入了400例HNSCC队列,并进行了长期随访分析.我们调查了HNSCC的当前HPV患病率，独特的HPV相关患者特征，以及中国南方人群的患者预后。我们的发现表明，扁桃体中HPV相关口咽HNSCC的易感性很强，并且与HPV状态相关的继发性原发性肿瘤存在差异。我们的研究提供了中国南方人群中HPV相关HNSCC的最新情况，并阐述了与HNSCC预后相关的关键因素的理解。
