关键词: Alzheimer's disease Neurological disorders novel targets personalized medicine pharmaceutical interventions quality of life.

Mesh : Humans Nervous System Diseases / drug therapy therapy Drug Delivery Systems Genetic Therapy Animals Precision Medicine

来  源:   DOI:10.2174/0113816128284824240328071911

Abstract:
Neurological disorders impose a significant burden on individuals, leading to disabilities and a reduced quality of life. However, recent years have witnessed remarkable advancements in pharmaceutical interventions aimed at treating these disorders. This review article aims to provide an overview of the latest innovations and breakthroughs in neurological disorder treatment, with a specific focus on key therapeutic areas such as Alzheimer\'s disease, Parkinson\'s disease, multiple sclerosis, epilepsy, and stroke. This review explores emerging trends in drug development, including the identification of novel therapeutic targets, the development of innovative drug delivery systems, and the application of personalized medicine approaches. Furthermore, it highlights the integration of advanced therapeutic technologies such as gene therapy, optogenetics, and neurostimulation techniques. These technologies hold promise for precise modulation of neural circuits, restoration of neuronal function, and even disease modification. While these advancements offer hopeful prospects for more effective and tailored treatments, challenges such as the need for improved diagnostic tools, identification of new targets for intervention, and optimization of drug delivery methods will remain. By addressing these challenges and continuing to invest in research and collaboration, we can revolutionize the treatment of neurological disorders and significantly enhance the lives of those affected by these conditions.
摘要:
神经系统疾病给个体带来了巨大的负担,导致残疾和生活质量下降。然而,近年来,在旨在治疗这些疾病的药物干预方面取得了显著进展。本文旨在概述神经系统疾病治疗的最新创新和突破。特别关注阿尔茨海默病等关键治疗领域,帕金森病,多发性硬化症,癫痫,和中风。这篇综述探讨了药物开发的新兴趋势,包括鉴定新的治疗靶点,创新药物输送系统的发展,以及个性化医疗方法的应用。此外,它强调了先进的治疗技术的整合,如基因疗法,光遗传学,和神经刺激技术。这些技术有望精确调制神经回路,恢复神经元功能,甚至疾病的修改。虽然这些进步为更有效和定制的治疗提供了希望的前景,挑战,如需要改进的诊断工具,确定新的干预目标,药物递送方法的优化仍然存在。通过应对这些挑战并继续投资于研究和合作,我们可以彻底改变神经系统疾病的治疗方法,并显着改善受这些疾病影响的人的生活。
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