Abstract：
This comprehensive review delves into the intricate landscape of glycans and glycoconjugates, unraveling their multifaceted roles across diverse biological dimensions. From influencing fundamental cellular processes such as signaling, recognition, and adhesion to exerting profound effects at the molecular and genetic levels, these complex carbohydrate structures emerge as linchpins in cellular functions and interactions. The structural diversity of glycoconjugates, which can be specifically classified into glycoproteins, glycolipids, and proteoglycans, underscores their importance in shaping the architecture of cells. Beyond their structural roles, these molecules also play key functions in facilitating cellular communication and modulating recognition mechanisms. Further, glycans and glycoconjugates prove invaluable as biomarkers in disease diagnostics, particularly in cancer, where aberrant glycosylation patterns offer critical diagnostic cues. Furthermore, the review explores their promising therapeutic applications, ranging from the development of glycan-based nanomaterials for precise drug delivery to innovative interventions in cancer treatment. This review endeavors to comprehensively explore the intricate functions of glycans and glycoconjugates, with the primary goal of offering valuable insights into their extensive implications in both health and disease. Encompassing a broad spectrum of biological processes, the focus of the review aims to provide a comprehensive understanding of the significant roles played by glycans and glycoconjugates.
摘要：
这篇全面的综述深入探讨了聚糖和糖缀合物的复杂景观，在不同的生物学维度上解开他们多方面的角色。从影响基本的细胞过程，如信号，认可,以及在分子和遗传水平上产生深远影响的粘附力，这些复杂的碳水化合物结构是细胞功能和相互作用的关键。糖缀合物的结构多样性，可以具体分类为糖蛋白，糖脂,和蛋白聚糖，强调了它们在塑造细胞架构方面的重要性。除了他们的结构性角色，这些分子还在促进细胞通讯和调节识别机制方面发挥关键功能。Further,聚糖和糖缀合物作为疾病诊断中的生物标志物被证明是无价的，特别是在癌症中，其中异常的糖基化模式提供了关键的诊断线索。此外，这篇综述探讨了它们有前途的治疗应用，从用于精确药物递送的基于聚糖的纳米材料的开发到癌症治疗的创新干预。这篇综述试图全面探索聚糖和糖缀合物的复杂功能，主要目标是为它们在健康和疾病中的广泛影响提供有价值的见解。涵盖了广泛的生物过程，本综述的重点旨在全面了解聚糖和糖缀合物的重要作用.
