Abstract：
There is a dearth of studies on neuroimaging correlates of Bipolar Disorder (BD) in Multiple Sclerosis (MS). We describe the clinical profile and neuroimaging findings of four cases of MS with BD. Among them, two patients had multiple mood episodes preceding the neurological symptoms, one had concurrent manic and neurological symptoms, and one had multiple depressive episodes and an isolated steroid-induced manic episode. Frontal and temporal lobes, and Periventricular White Matter were involved in all four cases, and hence may be considered biological substrates of BD in MS. Larger studies are needed to validate the utility of these findings.
摘要：
关于多发性硬化症（MS）中双相情感障碍（BD）的神经影像学相关研究缺乏。我们描述了4例伴有BD的MS的临床特征和神经影像学发现。其中,两名患者在神经症状之前有多次情绪发作，一个人同时有躁狂和神经症状，其中一人有多次抑郁发作和孤立的类固醇诱导的躁狂发作.额叶和颞叶,四例患者均累及脑室周围白质,因此可以被认为是MS中BD的生物底物。需要更大规模的研究来验证这些发现的效用。
