抗癌剂 CCT128930 选择性抑制 TRPM7 的结构基础。
关键词: CCT128930 CP: Molecular biology TRP channel TRPM7 calcium cancer cryo-EM drug inhibitor lipids magnesium
Mesh : TRPM Cation Channels / metabolism antagonists & inhibitors Humans Antineoplastic Agents / pharmacology chemistry Protein Serine-Threonine Kinases / metabolism antagonists & inhibitors HEK293 Cells Molecular Dynamics Simulation Binding Sites Protein Binding Cryoelectron Microscopy 1-Naphthylamine / analogs & derivatives
来 源:
DOI:10.1016/j.celrep.2024.114108
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