PDF(Pubmed)
Abstract：
Visceral hypersensitivity, a common clinical manifestation of irritable bowel syndrome, may contribute to the development of chronic visceral pain, which is a major challenge for both patients and health providers. Neural circuits in the brain encode, store, and transfer pain information across brain regions. In this review, we focus on the anterior cingulate cortex and paraventricular nucleus of the hypothalamus to highlight the progress in identifying the neural circuits involved in visceral pain. We also discuss several neural circuit mechanisms and emphasize the importance of cross-species, multiangle approaches and the identification of specific neurons in determining the neural circuits that control visceral pain.
摘要：
内脏超敏反应，肠易激综合征的常见临床表现,可能有助于慢性内脏疼痛的发展，这对患者和医疗服务提供者都是一个重大挑战。大脑中的神经回路编码，store,并在大脑区域传递疼痛信息。在这次审查中,我们将重点放在下丘脑的前扣带回皮质和室旁核上，以强调识别与内脏疼痛有关的神经回路的进展。我们还讨论了几种神经回路机制，并强调了跨物种的重要性，多角度方法和确定控制内脏疼痛的神经回路的特定神经元。
