PDF(Pubmed)
Abstract：
On average, aging is associated with unfavorable changes in cellular metabolism, which are the processes involved in the storage and expenditure of energy. However, metabolic dysregulation may not occur to the same extent in all older individuals as people age at different rates. Those who are aging rapidly are at increased risk of adverse health outcomes and are said to be \"frail.\" Here, we explore the links between frailty and metabolism, including metabolic contributors and consequences of frailty. We examine how metabolic diseases may modify the degree of frailty in old age and suggest that frailty may predispose toward metabolic disease. Metabolic interventions that can mitigate the degree of frailty in people are reviewed. New treatment strategies developed in animal models that are poised for translation to humans are also considered. We suggest that maintaining a youthful metabolism into older age may be protective against frailty.
摘要：
平均而言,衰老与细胞代谢的不利变化有关，这是能量储存和消耗所涉及的过程。然而,代谢失调在所有老年个体中的发生程度可能与不同年龄的个体发生程度不同.那些快速衰老的人面临着增加的不良健康结果的风险，据说他们很虚弱。\"这里,我们探索虚弱和新陈代谢之间的联系，包括代谢因素和虚弱的后果。我们研究了代谢疾病如何改变老年人的虚弱程度，并建议虚弱可能易患代谢疾病。回顾了可以减轻人们虚弱程度的代谢干预措施。还考虑了在动物模型中开发的新治疗策略，这些策略有望转化为人类。我们建议，保持年轻的新陈代谢到老年可能可以预防虚弱。
