Abstract：
UNASSIGNED: This study aimed to investigate the curative effect of motherwort combined with ethinylestradiol-cyproterone acetate (EE/CPA) on dysfunctional uterine bleeding (DUB).
UNASSIGNED: Atotal of 68 patients with DUB were divided into a single medication group (treated with EE/CPA) and a combination medication group(treated with motherwort and EE/CPA). The clinical efficacy, uterine hemodynamic parameters, sex hormone levels, coagulation index levels, blood routine test levels, and adverse reactions of patients were evaluated.
UNASSIGNED: After three months of treatment, total treatment response rate of the combination medication group was significantly higher than that of the single medication group. Decreased uterine volume, endometrial thickness and resistance index (RI), increased pulsatility index(PI), average flow rate, and uterine artery blood flow, as well asreduced follicle-stimulating hormone (FSH), luteinizing hormone (LH),estradiol (E2), progesterone (P), activated partial thromboplastin time (aPTT), prothrombin time (PT), fibrinogen (FIB), thrombin time(TT), platelet count (PLT), red blood cell (RBC), and hemoglobin (Hb)levels were witnessed in patients of the two groups. In thecombination medication group, there exhibited reduced uterine volume, endometrial thickness and RI, elevated PI, average flow rate, and uterine artery blood flow, reduced P, E2, FSH, LH, aPTT, PT, FIB, TT,PLT, RBC, and Hb levels in comparison to the single medication group.
UNASSIGNED: The combination of motherwort and EE/CPA is clinically effective in the treatment of DUB.
UNASSIGNED: Atotal of 68 patients with DUB were divided into a single medication group (treated with EE/CPA) and a combination medication group(treated with motherwort and EE/CPA). The clinical efficacy, uterine hemodynamic parameters, sex hormone levels, coagulation index levels, blood routine test levels, and adverse reactions of patients were evaluated.
UNASSIGNED: After three months of treatment, total treatment response rate of the combination medication group was significantly higher than that of the single medication group. Decreased uterine volume, endometrial thickness and resistance index (RI), increased pulsatility index(PI), average flow rate, and uterine artery blood flow, as well asreduced follicle-stimulating hormone (FSH), luteinizing hormone (LH),estradiol (E2), progesterone (P), activated partial thromboplastin time (aPTT), prothrombin time (PT), fibrinogen (FIB), thrombin time(TT), platelet count (PLT), red blood cell (RBC), and hemoglobin (Hb)levels were witnessed in patients of the two groups. In thecombination medication group, there exhibited reduced uterine volume, endometrial thickness and RI, elevated PI, average flow rate, and uterine artery blood flow, reduced P, E2, FSH, LH, aPTT, PT, FIB, TT,PLT, RBC, and Hb levels in comparison to the single medication group.
UNASSIGNED: The combination of motherwort and EE/CPA is clinically effective in the treatment of DUB.
摘要：
■本研究旨在探讨益母草联合炔雌醇环丙孕酮（EE/CPA）治疗功能失调性子宫出血（DUB）的疗效。
■总共68例DUB患者被分为单一药物组（用EE/CPA治疗）和联合药物组（用益母草和EE/CPA治疗）。临床疗效,子宫血流动力学参数，性激素水平,凝血指标水平,血常规检测水平,并对患者的不良反应进行评价。
■经过三个月的治疗，联合用药组治疗总有效率明显高于单一用药组。子宫体积减少,子宫内膜厚度和阻力指数（RI），增加的搏动指数（PI），平均流量,子宫动脉血流，以及减少的促卵泡激素（FSH），黄体生成素(LH),雌二醇（E2），孕酮（P），活化的部分血栓形成时间（aPTT），凝血酶原时间（PT），纤维蛋白原（FIB），凝血酶时间（TT），血小板计数(PLT),红细胞（RBC），观察两组患者的血红蛋白（Hb）水平。在联合用药组中，表现出子宫体积减少，子宫内膜厚度和RI,PI升高,平均流量,子宫动脉血流,减少P,E2,FSH,LH,aPTT,PT,FIB,TT,PLT,红细胞,与单一药物组相比，Hb水平。
■益母草和EE/CPA的联合治疗在临床上是有效的。
■总共68例DUB患者被分为单一药物组（用EE/CPA治疗）和联合药物组（用益母草和EE/CPA治疗）。临床疗效,子宫血流动力学参数，性激素水平,凝血指标水平,血常规检测水平,并对患者的不良反应进行评价。
■经过三个月的治疗，联合用药组治疗总有效率明显高于单一用药组。子宫体积减少,子宫内膜厚度和阻力指数（RI），增加的搏动指数（PI），平均流量,子宫动脉血流，以及减少的促卵泡激素（FSH），黄体生成素(LH),雌二醇（E2），孕酮（P），活化的部分血栓形成时间（aPTT），凝血酶原时间（PT），纤维蛋白原（FIB），凝血酶时间（TT），血小板计数(PLT),红细胞（RBC），观察两组患者的血红蛋白（Hb）水平。在联合用药组中，表现出子宫体积减少，子宫内膜厚度和RI,PI升高,平均流量,子宫动脉血流,减少P,E2,FSH,LH,aPTT,PT,FIB,TT,PLT,红细胞,与单一药物组相比，Hb水平。
■益母草和EE/CPA的联合治疗在临床上是有效的。
