PDF(Pubmed)
Abstract：
Neutrophil extracellular traps (NETs), composed of DNA, histones, and antimicrobial proteins, are released by neutrophils in response to pathogens but are also recognized for their involvement in a range of pathological processes, including autoimmune diseases, cancer, and cardiovascular diseases. This review explores the intricate roles of NETs in different cardiovascular conditions such as thrombosis, atherosclerosis, myocardial infarction, COVID-19, and particularly in the pathogenesis of abdominal aortic aneurysms. We elucidate the mechanisms underlying NET formation and function, provide a foundational understanding of their biological significance, and highlight the contribution of NETs to inflammation, thrombosis, and tissue remodeling in vascular disease. Therapeutic strategies for preventing NET release are compared with approaches targeting components of formed NETs in cardiovascular disease. Current limitations and potential avenues for clinical translation of anti-NET treatments are discussed.
摘要：
中性粒细胞胞外诱捕器（NET），由DNA组成，组蛋白,和抗菌蛋白，由嗜中性粒细胞响应病原体而释放，但也因其参与一系列病理过程而被认可，包括自身免疫性疾病,癌症,和心血管疾病。这篇综述探讨了NETs在不同心血管疾病中的复杂作用，如血栓形成，动脉粥样硬化,心肌梗塞,COVID-19，特别是在腹主动脉瘤的发病机理中。我们阐明了NET形成和功能的潜在机制，提供对其生物学意义的基础理解，并强调NET对炎症的贡献，血栓形成,血管疾病中的组织重塑。将预防NET释放的治疗策略与针对心血管疾病中形成的NET的成分的方法进行了比较。讨论了抗NET治疗临床翻译的当前局限性和潜在途径。
