PDF(Pubmed)
Abstract：
Trueperella pyogenes can cause various infections in the organs and tissues of different livestock (including pigs, cows, goats, and sheep), including mastitis, endometritis, pneumonia, or abscesses. Moreover, diseases induced by T. pyogenes cause significant economic losses in animal husbandry. In recent large-scale investigations, T. pyogenes has been identified as one of the main pathogens causing endometritis in lactating cows. However, the main treatment for the above-mentioned diseases is still currently antibiotic therapy. Understanding the impact of endometritis associated with T. pyogenes on the fertility of cows can help optimize antibiotic treatment for uterine diseases, thereby strategically concentrating the use of antimicrobials on the most severe cases. Therefore, it is particularly important to continuously monitor the prevalence of T. pyogenes and test its drug resistance. This study compared the uterine microbiota of healthy cows and endometritis cows in different cattle farms, investigated the prevalence of T. pyogenes, evaluated the genetic characteristics and population structure of isolated strains, and determined the virulence genes and drug resistance characteristics of T. pyogenes. An amount of 186 dairy cows were involved in this study and 23 T. pyogenes strains were isolated and identified from the uterine lavage fluid of dairy cows with or without endometritis.
摘要：
化脓性梭菌可在不同家畜(包括猪,奶牛,山羊,和绵羊)，包括乳腺炎,子宫内膜炎,肺炎,或脓肿。此外，化脓性毛虫引起的疾病在畜牧业中造成了巨大的经济损失。在最近的大规模调查中，化脓性芽孢杆菌已被确定为在泌乳奶牛中引起子宫内膜炎的主要病原体之一。然而,目前，上述疾病的主要治疗方法仍然是抗生素治疗。了解与化脓性衣原体相关的子宫内膜炎对奶牛生育能力的影响可以帮助优化抗生素治疗子宫疾病，从而战略性地集中在最严重的病例上使用抗菌药物。因此,持续监测化脓性产脓毒菌的流行情况并检测其耐药性尤为重要。这项研究比较了不同牛场的健康奶牛和子宫内膜炎奶牛的子宫微生物群，调查了化脓杆菌的患病率，评估了分离菌株的遗传特征和种群结构，并测定了化脓杆菌的毒力基因和耐药特性。本研究涉及186头奶牛，从有或没有子宫内膜炎的奶牛的子宫灌洗液中分离并鉴定了23个化脓性产热杆菌菌株。
