PDF(Pubmed)
Abstract：
Flow cytometry is a mainstay technique in cell biology research, where it is used for phenotypic analysis of mixed cell populations. Quantitative approaches have unlocked a deeper value of flow cytometry in drug discovery research. As the number of drug modalities and druggable mechanisms increases, there is an increasing drive to identify meaningful biomarkers, evaluate the relationship between pharmacokinetics and pharmacodynamics (PK/PD), and translate these insights into the evaluation of patients enrolled in early clinical trials. In this review, we discuss emerging roles for flow cytometry in the translational setting that supports the transition and evaluation of novel compounds in the clinic.
摘要：
流式细胞术是细胞生物学研究的主要技术,用于混合细胞群的表型分析。定量方法已经解锁了流式细胞术在药物发现研究中的更深层次的价值。随着药物模式和药物机制的增加，识别有意义的生物标志物的动力越来越强，评估药代动力学和药效学（PK/PD）之间的关系，并将这些见解转化为对参加早期临床试验的患者的评估。在这次审查中,我们讨论了流式细胞术在翻译环境中的新兴作用，支持新化合物在临床中的转变和评估。
