PDF(Pubmed)
Abstract：
Nowadays, drug delivery systems (DDSs) are gaining more and more attention. Conducting polymers (CPs) are efficiently used for DDS construction as such systems can be used in therapy. In this research, a well-known CP, polypyrrole (PPy), was synthesized in the presence of the polysaccharide heparin (HEP) and chlorpromazine (CPZ) using sodium dodecyl sulfate (SDS) as electrolyte on a steel substrate. The obtained results demonstrate the successful incorporation of CPZ and HEP into the polymer matrix, with the deposited films maintaining stable electrochemical parameters across multiple doping/dedoping cycles. Surface roughness, estimated via AFM analysis, revealed a correlation with layer thickness-decreasing for thinner layers and increasing for thicker ones. Moreover, SEM images revealed a change in the morphology of PPy films when PPy is electropolymerized in the presence of CPZ and HEP, while FTIR confirmed the presence of CPZ and HEP within PPy. Due to its lower molecular mass compared to HEP, CPZ was readily integrated into the thin polymer matrix during deposition, with diffusion being unimpeded, as opposed to films with greater thickness. Finally, the resulting system exhibited the ability to release CPZ, enabling a dosing range of 10 mg to 20 mg per day, effectively covering the therapeutic concentration range.
摘要：
如今,给药系统(DDS)正受到越来越多的关注。导电聚合物(CP)有效地用于DDS构造,因为这样的系统可用于治疗。在这项研究中,一个著名的CP,聚吡咯（PPy），在钢基材上使用十二烷基硫酸钠（SDS）作为电解质，在多糖肝素（HEP）和氯丙嗪（CPZ）的存在下合成。获得的结果表明，CPZ和HEP成功地掺入到聚合物基质中，沉积膜在多个掺杂/去掺杂循环中保持稳定的电化学参数。表面粗糙度,通过AFM分析估计，揭示了与层厚度的相关性-较薄的层减少，较厚的层增加。此外，SEM图像显示PPy在CPZ和HEP存在下电聚合时，PPy膜的形态发生变化，而FTIR证实PPy中存在CPZ和HEP。由于其分子量低于HEP，CPZ在沉积过程中很容易整合到薄聚合物基质中，扩散不受阻碍，与厚度更大的薄膜相反。最后,由此产生的系统表现出释放CPZ的能力，使剂量范围为每天10毫克至20毫克，有效覆盖治疗浓度范围。
