PDF(Pubmed)
Abstract：
Cancers of the reproductive organs, including prostate, bladder, ovarian, and cervical cancers, are considered the most common causes of death in both sexes worldwide. The genus Vaccinium L. (Ericaceae) comprises fleshy berry crop species, including cranberries, blueberries, lingonberries, bilberries, and bog bilberries, and are widely distributed in many countries. Flavonols, anthocyanins (ACNs), proanthocyanidins (PACs), and phenolic acids are the most bioactive compounds naturally found in Vaccinium berries and have been extensively used as anticancer agents. However, it remains uncertain whether Vaccinium bioactives have a therapeutic role in reproductive cancers (RCs), and how these bioactives could be effective in modulating RC-related signalling pathways/molecular genes. Therefore, this article aims to review existing evidence in the PubMed/MEDLINE database on Vaccinium berries\' major bioactive compounds in RC treatment and unravel the mechanisms underlying this process.
摘要：
生殖器官的癌症，包括前列腺,膀胱,卵巢,和宫颈癌，被认为是全世界男女最常见的死亡原因。越华树属（马齿科）包括肉质浆果作物物种，包括小红莓,蓝莓,越橘,越橘,沼泽越莓，并广泛分布在许多国家。黄酮醇,花色苷（ACN），原花青素（PAC），和酚酸是天然存在于越橘浆果中的最具生物活性的化合物，已被广泛用作抗癌剂。然而,目前尚不确定Vaccinium生物活性物质是否在生殖癌症（RC）中具有治疗作用，以及这些生物活性物质如何有效调节RC相关的信号通路/分子基因。因此,本文旨在回顾PubMed/MEDLINE数据库中有关越橘浆果RC治疗中主要生物活性化合物的现有证据，并阐明这一过程的潜在机制。
