PDF(Pubmed)
Abstract：
Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer and the third contributor to malignancy-related deaths worldwide. The hepatic venous pressure gradient (HVPG), transient elastography-liver stiffness measurement (TE-LSM), and the association between TBS (tumor burden score), alpha-fetoprotein levels, and the Child-Pugh classification (TAC score) can serve as valuable prognostic indicators for these patients. Therefore, the main objective of our research was to analyze the prognostic value of the HVPG, TE-LSM, TBS, and TAC scores. An observational and survival study was conducted on 144 subjects. Our findings indicated that HVPG greater than 10 mmHg, AFP surpassing 400 ng/mL, an advanced C-P class, and low TAC score are independent predictors of overall survival. During the multivariate analysis, AFP serum levels and C-P class proved statistically significant. The present study revealed significant differences in overall survival between the two groups divided upon HVPG values and settled by the cutoff of 10 mmHg (p = 0.02). Moreover, by dividing the cohort into three groups based on the TAC score (very low, low, and moderate), statistically significant differences in overall survival were observed across the groups (p = 0.004).
摘要：
肝细胞癌（HCC）是原发性肝癌的主要形式，也是全球恶性肿瘤相关死亡的第三大因素。肝静脉压力梯度（HVPG），瞬时弹性成像-肝脏硬度测量(TE-LSM)，和TBS(肿瘤负荷评分)之间的关联，甲胎蛋白水平,Child-Pugh分类(TAC评分)可以作为这些患者的有价值的预后指标。因此,我们研究的主要目的是分析HVPG的预后价值，TE-LSM,TBS,和TAC得分。对144名受试者进行了观察和生存研究。我们的发现表明HVPG大于10mmHg，AFP超过400ng/mL，高级C-P课程，低TAC评分是总生存率的独立预测因子。在多变量分析中，AFP血清水平和C-P等级被证明具有统计学意义。本研究显示，两组之间的总体生存率存在显着差异，按HVPG值划分，并以10mmHg的临界值确定（p=0.02）。此外，通过根据TAC评分将队列分为三组(非常低，低,和中等），观察到各组总生存期的统计学差异(p=0.004).
