PDF(Pubmed)
Abstract：
The N-myc downstream regulated gene family (NDRGs) includes four members: NDRG1, NDRG2, NDRG3, and NDRG4. These members exhibit 53-65% amino acid identity. The role of NDRGs in tumor growth and metastasis appears to be tumor- and context-dependent. While many studies have reported that these family members have tumor suppressive roles, recent studies have demonstrated that NDRGs, particularly NDRG1 and NDRG2, function as oncogenes, promoting tumor growth and metastasis. Additionally, NDRGs are involved in regulating different signaling pathways and exhibit diverse cellular functions in breast cancers. In this review, we comprehensively outline the oncogenic and tumor suppressor roles of the NDRG family members in breast cancer, examining evidence from in vitro and in vivo breast cancer models as well as tumor tissues from breast cancer patients. We also present analyses of publicly available genomic and transcriptomic data from multiple independent cohorts of breast cancer patients.
摘要：
N-myc下游调节基因家族(NDRG)包括四个成员:NDRG1、NDRG2、NDRG3和NDRG4。这些成员表现出53-65%的氨基酸同一性。NDRG在肿瘤生长和转移中的作用似乎是肿瘤和环境依赖性的。虽然许多研究报道这些家族成员具有肿瘤抑制作用，最近的研究表明，NDRG，特别是NDRG1和NDRG2，作为癌基因，促进肿瘤生长和转移。此外,NDRG参与调节不同的信号通路，并在乳腺癌中表现出不同的细胞功能。在这次审查中,我们全面概述了NDRG家族成员在乳腺癌中的致癌和抑癌作用，检查来自体外和体内乳腺癌模型以及乳腺癌患者的肿瘤组织的证据。我们还提供了对来自多个独立乳腺癌患者队列的公开可用基因组和转录组数据的分析。
