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Abstract：
OBJECTIVE: Evaluation of the influence of intrinsic and extrinsic conditions on ablation zone volumes (AZV) after microwave ablation (MWA).
METHODS: Retrospective analysis of 38 MWAs of therapy-naïve liver tumours performed with the NeuWave PR probe. Ablations were performed either in the \'standard mode\' (65 W, 10 min) or in the \'surgical mode\' (95 W, 1 min, then 65 W, 10 min). AZV measurements were obtained from contrast-enhanced computed tomography immediately post-ablation.
RESULTS: AZVs in the \'standard mode\' were smaller than predicted by the manufacturer (length 3.6 ± 0.6 cm, 23% below 4.7 cm; width 2.7 ± 0.6, 23% below 3.5 cm). Ablation zone past the tip was limited to 6 mm in 28/32 ablations. Differences in AZV between the \'surgical mode\' and \'standard mode\' were not significant (15.6 ± 7.8 mL vs. 13.9 ± 8.8 mL, p = 0.6). AZVs were significantly larger in case of hepatocellular carcinomas (HCCs) (n = 19) compared to metastasis (n = 19; 17.8 ± 9.9 mL vs. 10.1 ± 5.1 mL, p = 0.01) and in non-perivascular tumour location (n = 14) compared to perivascular location (n = 24, 18.7 ± 10.4 mL vs. 11.7 ± 6.1 mL, p = 0.012), with both factors remaining significant in two-way analysis of variance (HCC vs. metastasis: p = 0.02; perivascular vs. non-perivascular tumour location: p = 0.044).
CONCLUSIONS: Larger AZVs can be expected in cases of HCCs compared with metastases and in non-perivascular locations. Using the \'surgical mode\' does not increase AZV significantly.
METHODS: Retrospective analysis of 38 MWAs of therapy-naïve liver tumours performed with the NeuWave PR probe. Ablations were performed either in the \'standard mode\' (65 W, 10 min) or in the \'surgical mode\' (95 W, 1 min, then 65 W, 10 min). AZV measurements were obtained from contrast-enhanced computed tomography immediately post-ablation.
RESULTS: AZVs in the \'standard mode\' were smaller than predicted by the manufacturer (length 3.6 ± 0.6 cm, 23% below 4.7 cm; width 2.7 ± 0.6, 23% below 3.5 cm). Ablation zone past the tip was limited to 6 mm in 28/32 ablations. Differences in AZV between the \'surgical mode\' and \'standard mode\' were not significant (15.6 ± 7.8 mL vs. 13.9 ± 8.8 mL, p = 0.6). AZVs were significantly larger in case of hepatocellular carcinomas (HCCs) (n = 19) compared to metastasis (n = 19; 17.8 ± 9.9 mL vs. 10.1 ± 5.1 mL, p = 0.01) and in non-perivascular tumour location (n = 14) compared to perivascular location (n = 24, 18.7 ± 10.4 mL vs. 11.7 ± 6.1 mL, p = 0.012), with both factors remaining significant in two-way analysis of variance (HCC vs. metastasis: p = 0.02; perivascular vs. non-perivascular tumour location: p = 0.044).
CONCLUSIONS: Larger AZVs can be expected in cases of HCCs compared with metastases and in non-perivascular locations. Using the \'surgical mode\' does not increase AZV significantly.
摘要：
目的：评估内在和外在条件对微波消融（MWA）后消融区体积（AZV）的影响。
方法：使用NeuWavePR探针对38例初治肝肿瘤进行回顾性分析。消融在“标准模式”(65W，10分钟)或“手术模式”(95瓦，1分钟,然后是65瓦，10分钟)。在消融后立即从对比增强计算机断层扫描获得AZV测量值。
结果：“标准模式”下的AZV比制造商预测的要小（长度3.6±0.6厘米，4.7厘米以下23%；宽度2.7±0.6，3.5厘米以下23%）。在28/32消融中,经过尖端的消融区限制为6mm。“手术模式”和“标准模式”之间的AZV差异不显着（15.6±7.8mL与13.9±8.8mL,p=0.6)。与转移相比，肝细胞癌（HCC）（n=19）的AZV明显更大（n=19；17.8±9.9mLvs.10.1±5.1mL,p=0.01）和非血管周围肿瘤位置（n=14）与血管周围位置（n=24，18.7±10.4mLvs.11.7±6.1mL,p=0.012),在双向方差分析中，这两个因素都保持显著(HCC与转移：p=0.02；血管周围vs.非血管周围肿瘤位置：p=0.044）。
结论：与转移和非血管周围位置相比，在肝癌病例中可以预期更大的AZV。使用“手术模式”不会显着增加AZV。
方法：使用NeuWavePR探针对38例初治肝肿瘤进行回顾性分析。消融在“标准模式”(65W，10分钟)或“手术模式”(95瓦，1分钟,然后是65瓦，10分钟)。在消融后立即从对比增强计算机断层扫描获得AZV测量值。
结果：“标准模式”下的AZV比制造商预测的要小（长度3.6±0.6厘米，4.7厘米以下23%；宽度2.7±0.6，3.5厘米以下23%）。在28/32消融中,经过尖端的消融区限制为6mm。“手术模式”和“标准模式”之间的AZV差异不显着（15.6±7.8mL与13.9±8.8mL,p=0.6)。与转移相比，肝细胞癌（HCC）（n=19）的AZV明显更大（n=19；17.8±9.9mLvs.10.1±5.1mL,p=0.01）和非血管周围肿瘤位置（n=14）与血管周围位置（n=24，18.7±10.4mLvs.11.7±6.1mL,p=0.012),在双向方差分析中，这两个因素都保持显著(HCC与转移：p=0.02；血管周围vs.非血管周围肿瘤位置：p=0.044）。
结论：与转移和非血管周围位置相比，在肝癌病例中可以预期更大的AZV。使用“手术模式”不会显着增加AZV。
