METHODS: A hospital-dependent retrospective observational study (total: n = 377; male, n = 213; and female, n = 164 participants) was undertaken. COVID-19 exposure was assessed by performing real-time PCR on nasopharyngeal (NP) swabs. Descriptive and inferential statistics were applied for both continuous and categorical variables using Rstudio-version-4.0.2. Pearson correlation and regression were executed with a cut-off of p < 0.05 for evaluating significance. Data representation by R-packages and ggplot2.
RESULTS: A significant variation in the mean ± SD (highly-sever (HS)/moderately severe (MS)) of CRP (HS/MS: 102.4 ± 22.9/21.3 ± 6.9, p-value < 0.001), D-dimer (HS/MS: 661.1 ± 80.6/348.7 ± 42.9, p-value < 0.001), and ferritin (HS/MS: 875.8 ± 126.8/593.4 ± 67.3, p-value < 0.001) were observed. Thrombocytopenia, high PT, and PTT exhibited an association with the HS individuals (p < 0.001). CRP was correlated with neutrophil (r = 0.77), ferritin (r = 0.74), and WBC (r = 0.8). D-dimer correlated with platelets (r = -0.82), PT (r = 0.22), and PTT (r = 0.37). The adjusted odds ratios (Ad-OR) of CRP, ferritin, D-dimer, platelet, PT, and PTT for HS compared to MS were 1.30 (95% CI -1.137, 1.50; p < 0.001), 1.048 (95% CI -1.03, 1.066; p < 0.001), 1.3 (95% CI -1.24, 1.49, p > 0.05), -0.813 (95% CI -0.734, 0.899, p < 0.001), 1.347 (95% CI -1.15, 1.57, p < 0.001), and 1.234 (95% CI -1.16, 1.314, p < 0.001), respectively.
CONCLUSIONS: SARS-CoV-2 caused alterations in vital laboratory parameters and raised ferritin, CRP, and D-dimer presented an association with disease severity at a significant level.
方法:一项依赖医院的回顾性观察性研究(总计:n=377;男性,n=213;女性,n=164名参与者)。通过对鼻咽(NP)拭子进行实时PCR评估COVID-19暴露。使用Rstudio-version-4.0.2对连续变量和分类变量都应用了描述性和推断性统计数据。进行Pearson相关和回归,截止值p<0.05,以评估显著性。由R-packages和ggplot2表示的数据。
结果:CRP的平均值±SD(高度严重(HS)/中度严重(MS))的显着变化(HS/MS:102.4±22.9/21.3±6.9,p值<0.001),D-二聚体(HS/MS:661.1±80.6/348.7±42.9,p值<0.001),观察到铁蛋白(HS/MS:875.8±126.8/593.4±67.3,p值<0.001)。血小板减少症,高PT,和PTT表现出与HS个体的相关性(p<0.001)。CRP与中性粒细胞呈正相关(r=0.77),铁蛋白(r=0.74),和白细胞(r=0.8)。D-二聚体与血小板相关(r=-0.82),PT(r=0.22),和PTT(r=0.37)。CRP的调整比值比(Ad-OR),铁蛋白,D-二聚体,血小板,PT,与MS相比,HS的PTT为1.30(95%CI-1.137,1.50;p<0.001),1.048(95%CI-1.03,1.066;p<0.001),1.3(95%CI-1.24,1.49,p>0.05),-0.813(95%CI-0.734,0.899,p<0.001),1.347(95%CI-1.15,1.57,p<0.001),和1.234(95%CI-1.16,1.314,p<0.001),分别。
结论:SARS-CoV-2引起了重要实验室参数的改变,并升高了铁蛋白,CRP,D-二聚体与疾病严重程度有显著关联。