PDF(Pubmed)
Abstract：
BACKGROUND: The aim was to validate the correlation between corneal shape parameters and axial length growth (ALG) during orthokeratology using Image-Pro Plus (IPP) 6.0 software.
METHODS: This retrospective study used medical records of myopic children aged 8-13 years (n = 104) undergoing orthokeratology. Their corneal topography and axial length were measured at baseline and subsequent follow-ups after lens wear. Corneal shape parameters, including the treatment zone (TZ) area, TZ diameter, TZ fractal dimension, TZ radius ratio, eccentric distance, pupil area, and pupillary peripheral steepened zone(PSZ) area, were measured using IPP software. The impact of corneal shape parameters at 3 months post-orthokeratology visit on 1.5-year ALG was evaluated using multivariate linear regression analysis.
RESULTS: ALG exhibited significant associations with age, TZ area, TZ diameter, TZ fractal dimension, and eccentric distance on univariate linear regression analysis. Multivariate regression analysis identified age, TZ area, and eccentric distance as significantly correlated with ALG (all P < 0.01), with eccentric distance showing the strongest correlation (β = -0.370). The regressive equation was y = 1.870 - 0.235a + 0.276b - 0.370c, where y represents ALG, a represents age, b represents TZ area, and c represents eccentric distance; R2 = 0.27). No significant relationships were observed between the TZ radius ratio, pupillary PSZ area, and ALG.
CONCLUSIONS: IPP software proves effective in capturing precise corneal shape parameters after orthokeratology. Eccentric distance, rather than age or the TZ area, significantly influences ALG retardation.
METHODS: This retrospective study used medical records of myopic children aged 8-13 years (n = 104) undergoing orthokeratology. Their corneal topography and axial length were measured at baseline and subsequent follow-ups after lens wear. Corneal shape parameters, including the treatment zone (TZ) area, TZ diameter, TZ fractal dimension, TZ radius ratio, eccentric distance, pupil area, and pupillary peripheral steepened zone(PSZ) area, were measured using IPP software. The impact of corneal shape parameters at 3 months post-orthokeratology visit on 1.5-year ALG was evaluated using multivariate linear regression analysis.
RESULTS: ALG exhibited significant associations with age, TZ area, TZ diameter, TZ fractal dimension, and eccentric distance on univariate linear regression analysis. Multivariate regression analysis identified age, TZ area, and eccentric distance as significantly correlated with ALG (all P < 0.01), with eccentric distance showing the strongest correlation (β = -0.370). The regressive equation was y = 1.870 - 0.235a + 0.276b - 0.370c, where y represents ALG, a represents age, b represents TZ area, and c represents eccentric distance; R2 = 0.27). No significant relationships were observed between the TZ radius ratio, pupillary PSZ area, and ALG.
CONCLUSIONS: IPP software proves effective in capturing precise corneal shape parameters after orthokeratology. Eccentric distance, rather than age or the TZ area, significantly influences ALG retardation.
摘要：
背景：目的是使用Image-ProPlus（IPP）6.0软件验证角膜塑形术期间角膜形状参数与眼轴长度生长（ALG）之间的相关性。
方法：这项回顾性研究使用了接受角膜塑形术的8-13岁近视儿童（n=104）的医疗记录。在佩戴镜片后的基线和随后的随访中测量他们的角膜地形图和轴向长度。角膜形状参数,包括治疗区（TZ）区域，TZ直径,TZ分形维数,TZ半径比,偏心距离,瞳孔面积,瞳孔周边陡化区(PSZ),使用IPP软件进行测量。角膜塑形术后3个月角膜形状参数对1.5年ALG的影响使用多元线性回归分析进行评估。
结果：ALG与年龄显著相关，TZ区,TZ直径,TZ分形维数,和偏心距离的单变量线性回归分析。多元回归分析确定的年龄，TZ区,偏心距与ALG显著相关(均P<0.01),偏心距离表现出最强的相关性(β=-0.370)。回归方程为y=1.870-0.235a+0.276b-0.370c，其中y表示ALG，a代表年龄,b代表TZ区,c代表偏心距离；R2=0.27）。TZ半径比之间没有观察到显著的关系，瞳孔PSZ区，ALG。
结论：IPP软件在角膜塑形术后获得精确的角膜形状参数方面被证明是有效的。偏心距离,而不是年龄或TZ区域，显著影响ALG延迟。
方法：这项回顾性研究使用了接受角膜塑形术的8-13岁近视儿童（n=104）的医疗记录。在佩戴镜片后的基线和随后的随访中测量他们的角膜地形图和轴向长度。角膜形状参数,包括治疗区（TZ）区域，TZ直径,TZ分形维数,TZ半径比,偏心距离,瞳孔面积,瞳孔周边陡化区(PSZ),使用IPP软件进行测量。角膜塑形术后3个月角膜形状参数对1.5年ALG的影响使用多元线性回归分析进行评估。
结果：ALG与年龄显著相关，TZ区,TZ直径,TZ分形维数,和偏心距离的单变量线性回归分析。多元回归分析确定的年龄，TZ区,偏心距与ALG显著相关(均P<0.01),偏心距离表现出最强的相关性(β=-0.370)。回归方程为y=1.870-0.235a+0.276b-0.370c，其中y表示ALG，a代表年龄,b代表TZ区,c代表偏心距离；R2=0.27）。TZ半径比之间没有观察到显著的关系，瞳孔PSZ区，ALG。
结论：IPP软件在角膜塑形术后获得精确的角膜形状参数方面被证明是有效的。偏心距离,而不是年龄或TZ区域，显著影响ALG延迟。
