Abstract：
To analyze the frequency of sequential oral squamous cell carcinomas (s-OSCC), preceded by oral potentially malignant disorders, and OSCC de novo (OSCC-dn) and explore differences in their clinicopathologic presentations.
A structured electronic search strategy identified studies that analyzed frequency, clinical, biological, demographic, biomarkers, and prognostic features of s-OSCC and OSCC-dn according to PRISMA guidelines in PubMed, Scopus, Cochrane Library, and Google Scholar, up to January 31, 2023. Inclusion criteria were original English, Spanish, Portuguese, French, Italian, and German cross-sectional, cohort, and case-control studies. The quality of studies was assessed using the Agency for Research and Health Quality tool and the Newcastle-Ottawa Scale tool.
The final selection included 40 studies. OSCC-dn and s-OSCC represent, respectively, 71% and 29% of cases of OSCC (P = .00), showing a higher percentage of T1 or of T1+T2 in s-OSCC (P < .0001). The association meta-analysis showed OSCC-dn with a significant association. The meta-analysis showed that s-OSCC was significantly associated with smaller tumor size, absence of distant metastases, relapses, male sex, and tumor sites different from tongue; and OSCC-dn was associated with more advanced tumor size, more regional and distant metastases, more advanced stages, and worse survival.
S-OSCC was less frequent than expected. OSCC-dn seems to have specific clinical, biological, and prognostic features. Future perspectives on oral cancer prevention should address novel approaches and alternatives to screening, such as urgent referral of OSCC-dn.
A structured electronic search strategy identified studies that analyzed frequency, clinical, biological, demographic, biomarkers, and prognostic features of s-OSCC and OSCC-dn according to PRISMA guidelines in PubMed, Scopus, Cochrane Library, and Google Scholar, up to January 31, 2023. Inclusion criteria were original English, Spanish, Portuguese, French, Italian, and German cross-sectional, cohort, and case-control studies. The quality of studies was assessed using the Agency for Research and Health Quality tool and the Newcastle-Ottawa Scale tool.
The final selection included 40 studies. OSCC-dn and s-OSCC represent, respectively, 71% and 29% of cases of OSCC (P = .00), showing a higher percentage of T1 or of T1+T2 in s-OSCC (P < .0001). The association meta-analysis showed OSCC-dn with a significant association. The meta-analysis showed that s-OSCC was significantly associated with smaller tumor size, absence of distant metastases, relapses, male sex, and tumor sites different from tongue; and OSCC-dn was associated with more advanced tumor size, more regional and distant metastases, more advanced stages, and worse survival.
S-OSCC was less frequent than expected. OSCC-dn seems to have specific clinical, biological, and prognostic features. Future perspectives on oral cancer prevention should address novel approaches and alternatives to screening, such as urgent referral of OSCC-dn.
摘要：
目的：分析口腔鳞状细胞癌（s-OSCC）的发生率，之前是口腔潜在的恶性疾病，和OSCCdenovo（OSCC-dn），并探讨其临床病理表现的差异。
方法：结构化电子搜索策略确定了分析频率的研究，临床,生物，人口统计学,生物标志物，根据PubMed的PRISMA指南，s-OSCC和OSCC-dn的预后特征，Scopus,科克伦图书馆,和谷歌学者，截至2023年1月31日。纳入标准是英文原件，西班牙语,葡萄牙语,法语,意大利语,和德国横截面，队列,和病例对照研究。使用研究和健康质量机构工具和纽卡斯尔-渥太华量表工具评估研究质量。
结果：最终选择包括40项研究。OSCC-dn和s-OSCC代表，分别,71%和29%的OSCC病例（P=.00），在s-OSCC中显示较高的T1或T1+T2百分比(P<0.0001)。关联荟萃分析显示OSCC-dn具有显著关联。荟萃分析显示，s-OSCC与较小的肿瘤大小显著相关，没有远处转移，复发,男性,和肿瘤部位与舌头不同；OSCC-dn与更晚期的肿瘤大小相关，更多的区域和远处转移，更先进的阶段，更糟糕的生存。
结论：S-OSCC的发生频率低于预期。OSCC-dn似乎有特定的临床，生物，和预后特征。关于口腔癌预防的未来观点应该解决筛查的新方法和替代方法。例如OSCC-dn的紧急转诊。
方法：结构化电子搜索策略确定了分析频率的研究，临床,生物，人口统计学,生物标志物，根据PubMed的PRISMA指南，s-OSCC和OSCC-dn的预后特征，Scopus,科克伦图书馆,和谷歌学者，截至2023年1月31日。纳入标准是英文原件，西班牙语,葡萄牙语,法语,意大利语,和德国横截面，队列,和病例对照研究。使用研究和健康质量机构工具和纽卡斯尔-渥太华量表工具评估研究质量。
结果：最终选择包括40项研究。OSCC-dn和s-OSCC代表，分别,71%和29%的OSCC病例（P=.00），在s-OSCC中显示较高的T1或T1+T2百分比(P<0.0001)。关联荟萃分析显示OSCC-dn具有显著关联。荟萃分析显示，s-OSCC与较小的肿瘤大小显著相关，没有远处转移，复发,男性,和肿瘤部位与舌头不同；OSCC-dn与更晚期的肿瘤大小相关，更多的区域和远处转移，更先进的阶段，更糟糕的生存。
结论：S-OSCC的发生频率低于预期。OSCC-dn似乎有特定的临床，生物，和预后特征。关于口腔癌预防的未来观点应该解决筛查的新方法和替代方法。例如OSCC-dn的紧急转诊。
