A structured electronic search strategy identified studies that analyzed frequency, clinical, biological, demographic, biomarkers, and prognostic features of s-OSCC and OSCC-dn according to PRISMA guidelines in PubMed, Scopus, Cochrane Library, and Google Scholar, up to January 31, 2023. Inclusion criteria were original English, Spanish, Portuguese, French, Italian, and German cross-sectional, cohort, and case-control studies. The quality of studies was assessed using the Agency for Research and Health Quality tool and the Newcastle-Ottawa Scale tool.
The final selection included 40 studies. OSCC-dn and s-OSCC represent, respectively, 71% and 29% of cases of OSCC (P = .00), showing a higher percentage of T1 or of T1+T2 in s-OSCC (P < .0001). The association meta-analysis showed OSCC-dn with a significant association. The meta-analysis showed that s-OSCC was significantly associated with smaller tumor size, absence of distant metastases, relapses, male sex, and tumor sites different from tongue; and OSCC-dn was associated with more advanced tumor size, more regional and distant metastases, more advanced stages, and worse survival.
S-OSCC was less frequent than expected. OSCC-dn seems to have specific clinical, biological, and prognostic features. Future perspectives on oral cancer prevention should address novel approaches and alternatives to screening, such as urgent referral of OSCC-dn.
方法:结构化电子搜索策略确定了分析频率的研究,临床,生物,人口统计学,生物标志物,根据PubMed的PRISMA指南,s-OSCC和OSCC-dn的预后特征,Scopus,科克伦图书馆,和谷歌学者,截至2023年1月31日。纳入标准是英文原件,西班牙语,葡萄牙语,法语,意大利语,和德国横截面,队列,和病例对照研究。使用研究和健康质量机构工具和纽卡斯尔-渥太华量表工具评估研究质量。
结果:最终选择包括40项研究。OSCC-dn和s-OSCC代表,分别,71%和29%的OSCC病例(P=.00),在s-OSCC中显示较高的T1或T1+T2百分比(P<0.0001)。关联荟萃分析显示OSCC-dn具有显著关联。荟萃分析显示,s-OSCC与较小的肿瘤大小显著相关,没有远处转移,复发,男性,和肿瘤部位与舌头不同;OSCC-dn与更晚期的肿瘤大小相关,更多的区域和远处转移,更先进的阶段,更糟糕的生存。
结论:S-OSCC的发生频率低于预期。OSCC-dn似乎有特定的临床,生物,和预后特征。关于口腔癌预防的未来观点应该解决筛查的新方法和替代方法。例如OSCC-dn的紧急转诊。