Abstract：
Trichothecenes are Fusarium mycotoxins with sesquiterpenoid structure, which are widely occurred in grains. Due to high efficiency and environmental friendliness, biological detoxification methods have been of great interest to treat this global food and feed safety concern. This review summarized the biological detoxification methods of trichothecenes from three aspects, biosorption, biotransformation and biotherapy. The detoxification efficiency, characteristics, mechanisms and limitations of different strategies were discussed in detail. Computer-aided design will bring a new research paradigm for more efficient discovery of biodetoxifier. Integrating different detoxification approaches assisted with computational tools will become a promising research direction in the future, which will help to maximize the detoxification effect, or provide precise detoxification programs for the coexistence of various toxins at different levels in actual production. In addition, technical and regulatory issues in practical application were also discussed. These findings contribute to the exploration of efficient, applicable and sustainable methods for trichothecenes detoxification, ensuring the safety of food and feed to reduce the deleterious effects of trichothecenes on humans and animals.
摘要：
三端孢霉烯是镰刀菌真菌毒素，具有倍半萜结构，广泛存在于谷物中。由于效率高，环境友好，生物解毒方法对解决这一全球食品和饲料安全问题非常感兴趣。本文从三个方面综述了单端孢霉烯的生物解毒方法,生物吸附，生物转化和生物治疗。排毒效率，特点,详细讨论了不同策略的机制和局限性。计算机辅助设计将为更有效地发现生物解毒剂带来新的研究范式。结合不同的解毒方法与计算工具将成为未来一个有前途的研究方向。这将有助于最大限度地发挥排毒效果，或为实际生产中不同水平的各种毒素共存提供精确的解毒方案。此外,还讨论了实际应用中的技术和监管问题。这些发现有助于探索高效，适用和可持续的单端孢菌解毒方法，确保食品和饲料的安全，以减少单端孢菌对人和动物的有害影响。
