Abstract：
UNASSIGNED: Previously, not six systemic inflammatory indices were evaluated in the diagnosis of early onset sepsis (EOS) in very low birth weight (VLBW, <1500g) premature infants.
UNASSIGNED: We evaluated the effectiveness of systemic inflammatory indices in the diagnosis of EOS in VLBW infants.
UNASSIGNED: Premature infants with birth weight <1500 g were included in the study. Six systemic inflammatory indices including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), pan-immune-inflammation value (PIV), and systemic inflammation response index (SIRI) were compared in patients with EOS (treatment group) and without EOS (control group).
UNASSIGNED: Of 917 infants enrolled, 204 infants were in the EOS group and 713 infants comprised the control group. NLR, MLR and SIRI values were significantly higher in the EOS group than in the control group (p < 0.001). The AUC value of SIRI for the predictivity of EOS was 0.803.
UNASSIGNED: The SIRI can be used together with other parameters as both an easily accessible and the reliable systemic inflammatory indices in the diagnosis of EOS in VLBW preterm infants.
UNASSIGNED: We evaluated the effectiveness of systemic inflammatory indices in the diagnosis of EOS in VLBW infants.
UNASSIGNED: Premature infants with birth weight <1500 g were included in the study. Six systemic inflammatory indices including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), pan-immune-inflammation value (PIV), and systemic inflammation response index (SIRI) were compared in patients with EOS (treatment group) and without EOS (control group).
UNASSIGNED: Of 917 infants enrolled, 204 infants were in the EOS group and 713 infants comprised the control group. NLR, MLR and SIRI values were significantly higher in the EOS group than in the control group (p < 0.001). The AUC value of SIRI for the predictivity of EOS was 0.803.
UNASSIGNED: The SIRI can be used together with other parameters as both an easily accessible and the reliable systemic inflammatory indices in the diagnosis of EOS in VLBW preterm infants.
摘要：
■以前，在极低出生体重（VLBW，<1500g)早产儿。
■我们评估了全身炎症指标在VLBW婴儿EOS诊断中的有效性。
■出生体重<1500g的早产儿纳入研究。六个全身炎症指标，包括中性粒细胞与淋巴细胞比率（NLR），血小板与淋巴细胞比率（PLR），单核细胞与淋巴细胞比率（MLR），全身免疫炎症指数（SII），泛免疫炎症值(PIV)，比较有EOS（治疗组）和无EOS（对照组）患者的全身炎症反应指数（SIRI）。
■注册的917名婴儿中，204名婴儿为EOS组，713名婴儿为对照组。NLR,EOS组的MLR和SIRI值显著高于对照组(p<0.001)。SIRI对EOS预测性的AUC值为0.803。
■SIRI可以与其他参数一起使用，作为诊断VLBW早产儿EOS的容易获得和可靠的全身性炎症指标。
■我们评估了全身炎症指标在VLBW婴儿EOS诊断中的有效性。
■出生体重<1500g的早产儿纳入研究。六个全身炎症指标，包括中性粒细胞与淋巴细胞比率（NLR），血小板与淋巴细胞比率（PLR），单核细胞与淋巴细胞比率（MLR），全身免疫炎症指数（SII），泛免疫炎症值(PIV)，比较有EOS（治疗组）和无EOS（对照组）患者的全身炎症反应指数（SIRI）。
■注册的917名婴儿中，204名婴儿为EOS组，713名婴儿为对照组。NLR,EOS组的MLR和SIRI值显著高于对照组(p<0.001)。SIRI对EOS预测性的AUC值为0.803。
■SIRI可以与其他参数一起使用，作为诊断VLBW早产儿EOS的容易获得和可靠的全身性炎症指标。
