Abstract：
Wound healing of the oral mucosa is an urgent problem in modern dental surgical practice. This research article presents and compares the findings of the investigations of the structural, physicochemical, and biological characteristics of two types of polymeric membranes used for the regeneration of oral mucosa. The membranes were prepared from poly(tetrafluoroethylene) (PTFE) and a copolymer of vinylidene fluoride and tetrafluoroethylene (VDF-TeFE) and analyzed via scanning electron microscopy, atomic force microscopy, X-ray diffraction analysis, and Fourier transform infrared spectroscopy. Investigation results obtained indicate that both types of membranes are composed of thin fibers: (0.57 ± 0.25) μm for PTFE membranes and (0.43 ± 0.14) μm for VDF-TeFE membranes. Moreover, the fibers of VDF-TeFE membranes exhibit distinct piezoelectric properties, which are confirmed by piezoresponse force microscopy and X-ray diffraction. Both types of membranes are hydrophobic: (139.7 ± 2.5)° for PTFE membranes and (133.5 ± 2.0)° for VDF-TeFE membranes. In vitro assays verify that both membrane types did not affect the growth and division of mice fibroblasts of the 3T3-L1 cell line, with a cell viability in the range of 88-101%. Finally, in vivo comparative experiments carried out using Wistar rats demonstrate that the piezoelectric VDF-TeFE membranes have a high ability to regenerate oral mucosa.
摘要：
口腔粘膜的伤口愈合是现代牙科手术实践中的紧迫问题。这篇研究文章介绍并比较了结构的调查结果，物理化学,两种用于口腔黏膜再生的聚合物膜的生物学特性。由聚（四氟乙烯）（PTFE）和偏二氟乙烯和四氟乙烯的共聚物（VDF-TeFE）制备膜，并通过扫描电子显微镜进行分析，原子力显微镜,X射线衍射分析,和傅里叶变换红外光谱。获得的研究结果表明，两种类型的膜均由细纤维组成：PTFE膜为（0.57±0.25）μm，VDF-TeFE膜为（0.43±0.14）μm。此外，VDF-TeFE膜的纤维表现出独特的压电性能，通过压电响应力显微镜和X射线衍射证实了这一点。两种类型的膜都是疏水性的:PTFE膜为(139.7±2.5)°,VDF-TeFE膜为(133.5±2.0)°。体外试验证实两种膜类型均不影响3T3-L1细胞系小鼠成纤维细胞的生长和分裂,细胞活力在88-101%的范围内。最后,使用Wistar大鼠进行的体内比较实验表明，压电VDF-TeFE膜具有很高的口腔粘膜再生能力。
