Abstract：
To address the issue of bacterial growth on fresh-cut fruits, this paper reports the synthesis of nanosized γ-cyclodextrin metal-organic frameworks (CD-MOFs) using an ultrasound-assisted method and their application as carriers of limonene for antibacterial active packaging. The effects of the processing parameters on the morphology and crystallinity of the CD-MOFs are investigated, and the results prove that the addition of methanol is the key to producing nanosized CD-MOFs. The limonene loading content of the nanosized CD-MOFs can reach approximately 170 mg g-1. The sustained-release behaviors of limonene in the CD-MOFs are evaluated. Molecular docking simulations reveal the distribution and binding sites of limonene in the CD-MOFs. CD-MOFs are deposited on the surfaces of polycaprolactone (PCL) nanofibers via an immersion method, and limonene-loaded CD-MOF@PCL nanofibers are prepared. The morphology, crystallinity, thermal stability, mechanical properties, and antibacterial activity of the nanofibers are also studied. The nanofiber film effectively inhibits bacterial growth and prolongs the shelf life of fresh-cut apples. This study provides a novel strategy for developing antibacterial active packaging materials based on CD-MOFs and PCL nanofibers.
摘要：
为了解决鲜切水果上细菌生长的问题，本文报道了使用超声辅助方法合成纳米γ-环糊精金属有机骨架（CD-MOFs）及其作为柠檬烯抗菌活性包装载体的应用。研究了工艺参数对CD-MOFs形态和结晶度的影响,结果表明，甲醇的加入是制备纳米CD-MOFs的关键。纳米尺寸CD-MOF的柠檬烯负载含量可达到约170mgg-1。评价柠檬烯在CD-MOF中的持续释放行为。分子对接模拟揭示了柠檬烯在CD-MOFs中的分布和结合位点。CD-MOF通过浸渍法沉积在聚己内酯（PCL）纳米纤维的表面，制备了负载柠檬烯的CD-MOF@PCL纳米纤维。形态学,结晶度热稳定性，机械性能，并研究了纳米纤维的抗菌活性。纳米纤维膜有效抑制细菌生长，延长鲜切苹果的货架期。本研究为开发基于CD-MOFs和PCL纳米纤维的抗菌活性包装材料提供了一种新的策略。
