PDF(Pubmed)
Abstract：
The uterine cervix is one of the key factors involved in ensuring a proper track of gestation and labor. At the end of the gestational period, the cervix undergoes extensive changes, which can be summarized as a transformation from a non-favorable cervix to one that is soft and prone to dilation. During a process called cervical ripening, fundamental remodeling of the cervical extracellular matrix (ECM) occurs. The cervical ripening process is a derivative of many interlocking and mutually driving biochemical and molecular pathways under the strict control of mediators such as inflammatory cytokines, nitric oxide, prostaglandins, and reactive oxygen species. A thorough understanding of all these pathways and learning about possible triggering factors will allow us to develop new, better treatment algorithms and therapeutic goals that could protect women from both dysfunctional childbirth and premature birth. This review aims to present the possible role of the NLRP3 inflammasome in the cervical ripening process, emphasizing possible mechanisms of action and regulatory factors.
摘要：
子宫颈是确保正确妊娠和分娩的关键因素之一。在妊娠期结束时，子宫颈经历了广泛的变化，这可以概括为从不利的子宫颈到柔软且易于扩张的子宫颈的转变。在一个叫做宫颈成熟的过程中，宫颈细胞外基质（ECM）发生基本重塑。宫颈成熟过程是在炎症细胞因子等介质的严格控制下，许多互锁和相互驱动的生化和分子途径的衍生物，一氧化氮,前列腺素,和活性氧。透彻了解所有这些途径并了解可能的触发因素将使我们能够开发新的，更好的治疗算法和治疗目标，可以保护妇女免受功能失调的分娩和早产。这篇综述旨在介绍NLRP3炎性体在宫颈成熟过程中的可能作用。强调可能的作用机制和调节因素。
