Abstract：
High-dose tigecycline is gradually being introduced for the treatment of serious infectious diseases due to the increasing difficulty in treating pan-resistant bacterial infections. However, the safety of high-dose tigecycline is controversial. We report the case of a 76-year-old female patient with cerebral hemorrhage who received high-dose tigecycline (100 mg q12h) with other drugs for ventilator-associated pneumonia. 25 days after admission, she developed acute liver failure, mainly manifested by abnormally high bilirubin, coagulation dysfunction, and gastrointestinal hemorrhage with hemorrhagic shock. According to the updated Roussel Uclaf causality assessment method, the patient\'s acute liver injury was most likely caused by tigecycline.
摘要：
由于治疗泛耐药细菌感染的难度越来越大，大剂量替加环素逐渐被引入治疗严重的感染性疾病。然而,大剂量替加环素的安全性存在争议.我们报告了一例76岁的女性脑出血患者，该患者接受了高剂量替加环素（100mgq12h）与其他药物治疗呼吸机相关性肺炎。入院后25天，她出现了急性肝功能衰竭,主要表现为胆红素异常升高,凝血功能障碍,消化道出血伴失血性休克。根据更新的RousselUclaf因果关系评估方法，患者的急性肝损伤很可能是由替加环素引起的。
