Abstract：
Methicillin-resistant Staphylococcus aureus (MRSA) is challenging to treat due to a lack of guidance for clinicians. The daptomycin and ceftaroline combination is promising for treating persistent MRSA bloodstream infections (BSIs). In this report, we present a case series of 7 patients who failed vancomycin and then were treated with daptomycin and ceftaroline for persistent MRSA BSIs. The median age (IQR) of the included patients was 59 (48-67), with 5 male and 2 female patients. Six patients (85.7%) had a clinical cure for their persistent BSIs. The median time (IQR) for sterilization of MRSA BSIs after initiation of daptomycin and ceftaroline combination was 2 days (1-3). Among the patients who had clinical cures, the median time for clinical cures (IQR) was 6 weeks (4.5-6 weeks). The combination of daptomycin and ceftaroline could be an excellent treatment option for persistent MRSA BSIs.
摘要：
由于缺乏对临床医生的指导，耐甲氧西林金黄色葡萄球菌（MRSA）的治疗具有挑战性。达托霉素和头孢洛林组合有望治疗持续性MRSA血流感染（BSIs）。在这份报告中,我们介绍了一个病例系列，包括7例万古霉素无效，然后接受达托霉素和头孢洛林治疗持续性MRSABSIs。纳入患者的中位年龄（IQR）为59（48-67），男性5例，女性2例。六名患者（85.7％）的持续BSI临床治愈。开始达托霉素和头孢洛林组合后，MRSABSIs灭菌的中位时间（IQR）为2天（1-3）。在临床治愈的患者中，中位临床治疗时间(IQR)为6周(4.5~6周).达托霉素和头孢洛林的组合可能是持续性MRSABSIs的极好治疗选择。
