PDF(Pubmed)
Abstract：
Introduction: The extract from the Mango Seed Kernel (MSK) has been documented to exhibit antibacterial activity against Gram-positive and Gram-negative bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa. This suggests that biomaterials containing MSK extract could be a viable alternative to conventional wound treatments, such as nanocrystalline silver dressings. Despite this potential, there is a notable gap in the literature regarding comparing the antibacterial effectiveness of MSK film dressings with nanocrystalline silver dressings. This study aimed to develop film dressings containing MSK extract and evaluate their antibacterial properties compared to nanocrystalline silver dressings. Additionally, the study aimed to assess other vital physical properties of these dressings critical for effective wound care. Materials and methods: We prepared MSK film dressings from two cultivars of mango from Thailand, \'Chokanan\' and \'Namdokmai\'. The inhibition-zone method was employed to determine the antibacterial property. The morphology and chemical characterization of the prepared MSK film dressings were examined with scanning electron microscopy (SEM) and Fourier-Transform Infrared Spectroscopy (FTIR), respectively. The absorption of pseudo-wound exudate and water vapor transmission rate (WVTR) of film dressings were evaluated. Results: The results showed that 40% of MSKC film dressing had the highest inhibition zone (20.00 ± 0.00 mm against S. aureus and 17.00 ± 1.00 mm against P. aeruginosa) and 20%, 30%, and 40% of MSKC and MSKN film dressings had inhibition zones similar to nanocrystalline silver dressing for both S. aureus and P. aeruginosa (p > 0.05). In addition, all concentrations of the MSK film dressings had low absorption capacity, and Chokanan MSK (MSKC) film dressings had a higher WVTR than Namdokmai MSK (MSKN) film dressings. Conclusion: 20%, 30%, and 40% of MSK film dressing is nearly as effective as nanocrystalline silver dressing. Therefore, it has the potential to be an alternative antibacterial dressing and is suitable for wounds with low exudate levels.
摘要：
简介：芒果籽粒（MSK）的提取物已被证明对革兰氏阳性和革兰氏阴性细菌具有抗菌活性，包括金黄色葡萄球菌和铜绿假单胞菌。这表明含有MSK提取物的生物材料可能是常规伤口治疗的可行替代方案。如纳米晶银敷料。尽管有这种潜力,在比较MSK膜敷料与纳米晶银敷料的抗菌效果的文献中存在显著的差距。本研究旨在开发含有MSK提取物的薄膜敷料，并与纳米晶银敷料相比评估其抗菌性能。此外,该研究旨在评估这些敷料对有效伤口护理至关重要的其他重要物理特性。材料和方法：我们从泰国的两个芒果品种中制备了MSK薄膜敷料，\'Chokanan\'和\'Namdokmai\'。采用抑制区法测定抗菌性能。用扫描电子显微镜(SEM)和傅里叶变换红外光谱(FTIR)对制备的MSK膜敷料进行了形貌和化学表征,分别。评估了薄膜敷料对假伤口渗出物的吸收和水蒸气透过率（WVTR）。结果：结果表明，40％的MSKC膜敷料具有最高的抑制区（对金黄色葡萄球菌为20.00±0.00mm，对铜绿假单胞菌为17.00±1.00mm）和20％，30%,40%的MSKC和MSKN膜敷料对金黄色葡萄球菌和铜绿假单胞菌具有与纳米晶银敷料相似的抑制区(p>0.05)。此外,所有浓度的MSK膜敷料都具有较低的吸收能力，ChokananMSK（MSKC）薄膜敷料的WVTR高于NamdokmaiMSK（MSKN）薄膜敷料。结论：20%,30%,40％的MSK薄膜敷料几乎与纳米晶银敷料一样有效。因此,它有可能成为替代抗菌敷料，适用于低渗出物水平的伤口。
