PDF(Pubmed)
Abstract：
UNASSIGNED: Although there have been many researches on the etiology and risk factors with the onset of hemifacial spasm, researches on the risk factors related to progression rate are limited. This study aims to analyze the risk factors related to the progression rate of hemifacial spasm.
UNASSIGNED: The study enrolled 142 patients who underwent microvascular decompression for hemifacial spasm. Based on the duration and severity of symptoms, patients were classified into rapid progression group and slow progression group. To analyze risk factors, univariate and multivariate logistic regression analyses were conducted. Of 142 patients with hemifacial spasm, 90(63.3%) were classified as rapid progression group, 52(36.7%) were classified as slow progression group.
UNASSIGNED: In the univariate analysis, there were significant statistical differences between the two groups in terms of age of onset (P = 0.021), facial nerve angle (P < 0.01), hypertension (P = 0.01), presence of APOE ε4 expression (P < 0.01) and different degrees of brainstem compression in the Root Entry Zone (P < 0.01). In the multivariable analyses, there were significant statistical differences between the two groups in terms of age of symptom onset (P < 0.01 OR = 6.591), APOE ε4 (P < 0.01 OR = 5.691), brainstem compression (P = 0.006 OR = 5.620), and facial nerve angle (P < 0.01 OR = 5.758). Furthermore, we found no significant correlation between the severity of facial spasms and the progression rate of the disease (t = 2.47, P = 0.12>0.05).
UNASSIGNED: According to our study, patients with facial nerve angle ≤ 96.5°, severer compression of the brainstem by offending vessels, an onset age > 45 years and positive expression of APOE ε4, may experience faster progression of hemifacial spasm.
UNASSIGNED: The study enrolled 142 patients who underwent microvascular decompression for hemifacial spasm. Based on the duration and severity of symptoms, patients were classified into rapid progression group and slow progression group. To analyze risk factors, univariate and multivariate logistic regression analyses were conducted. Of 142 patients with hemifacial spasm, 90(63.3%) were classified as rapid progression group, 52(36.7%) were classified as slow progression group.
UNASSIGNED: In the univariate analysis, there were significant statistical differences between the two groups in terms of age of onset (P = 0.021), facial nerve angle (P < 0.01), hypertension (P = 0.01), presence of APOE ε4 expression (P < 0.01) and different degrees of brainstem compression in the Root Entry Zone (P < 0.01). In the multivariable analyses, there were significant statistical differences between the two groups in terms of age of symptom onset (P < 0.01 OR = 6.591), APOE ε4 (P < 0.01 OR = 5.691), brainstem compression (P = 0.006 OR = 5.620), and facial nerve angle (P < 0.01 OR = 5.758). Furthermore, we found no significant correlation between the severity of facial spasms and the progression rate of the disease (t = 2.47, P = 0.12>0.05).
UNASSIGNED: According to our study, patients with facial nerve angle ≤ 96.5°, severer compression of the brainstem by offending vessels, an onset age > 45 years and positive expression of APOE ε4, may experience faster progression of hemifacial spasm.
摘要：
■虽然关于面肌痉挛发病的病因和危险因素的研究很多,与进展率相关的危险因素研究有限。本研究旨在分析与面肌痉挛进展率相关的危险因素。
■该研究纳入了142例接受面肌痉挛微血管减压术的患者。根据症状的持续时间和严重程度，患者分为快速进展组和慢进展组.分析风险因素，进行了单因素和多因素logistic回归分析.142例面肌痉挛患者,90例（63.3%）被归类为快速进展组，52（36.7％）被归类为缓慢进展组。
■在单变量分析中，两组发病年龄差异有统计学意义(P=0.021),面神经角(P<0.01),高血压（P=0.01），根入区存在APOEε4表达（P<0.01）和不同程度的脑干受压（P<0.01）。在多变量分析中，两组发病年龄差异有统计学意义(P<0.01,OR=6.591),APOEε4（P<0.01或=5.691），脑干压缩(P=0.006OR=5.620),面神经角(P<0.01,OR=5.758)。此外，我们发现面部痉挛的严重程度与疾病的进展率之间没有显着相关性（t=2.47，P=0.12>0.05）。
■根据我们的研究，面神经角度≤96.5°的患者，严重压迫脑干的血管，发病年龄>45岁和APOEε4阳性表达时，面肌痉挛的进展可能更快。
■该研究纳入了142例接受面肌痉挛微血管减压术的患者。根据症状的持续时间和严重程度，患者分为快速进展组和慢进展组.分析风险因素，进行了单因素和多因素logistic回归分析.142例面肌痉挛患者,90例（63.3%）被归类为快速进展组，52（36.7％）被归类为缓慢进展组。
■在单变量分析中，两组发病年龄差异有统计学意义(P=0.021),面神经角(P<0.01),高血压（P=0.01），根入区存在APOEε4表达（P<0.01）和不同程度的脑干受压（P<0.01）。在多变量分析中，两组发病年龄差异有统计学意义(P<0.01,OR=6.591),APOEε4（P<0.01或=5.691），脑干压缩(P=0.006OR=5.620),面神经角(P<0.01,OR=5.758)。此外，我们发现面部痉挛的严重程度与疾病的进展率之间没有显着相关性（t=2.47，P=0.12>0.05）。
■根据我们的研究，面神经角度≤96.5°的患者，严重压迫脑干的血管，发病年龄>45岁和APOEε4阳性表达时，面肌痉挛的进展可能更快。
