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Abstract：
Introduction Melanocyte dysfunction in vitiligo is considered to be due to genetics, inflammation, and autoimmunity. Research has shown that oxidative stress plays a significant role in triggering these conditions. Currently, there are several markers indicating hematological inflammation and oxidative stress. This study aimed to investigate the status of inflammation and oxidative stress markers in vitiligo. Methods This study included patients with vitiligo and age-gender-matched healthy controls. C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-high-density lipoprotein ratio (MHR) and extent of vitiligo were calculated and compared. Results The study included 138 participants (69 vitiligo and 69 controls). The mean was 41.46 years with a female predominance (55.1%). The patient group demonstrated higher levels of platelets, neutrophils, CRP, NLR, MLR, PLR, and HDL and lower levels of lymphocytes and HDL compared to the control group (p>0,05). The only significantly different value between the groups was MHR (p=0.03). The generalized vitiligo group demonstrated higher levels of platelets, neutrophils, monocytes, CRP, NLR, PLR, and MLR, and lower levels of lymphocytes and HDL compared to the localized group. The only significantly different values between the groups were MHR and MLR (p=0.02, p=0.03). Conclusion This study found that MHR and CRP values were higher in vitiligo patients. Additionally, MHR and MLR values were higher in patients with generalized vitiligo. These results suggest that MHR is a reliable indicator marker for systemic inflammation and oxidative stress in vitiligo.
摘要：
简介白癜风的黑素细胞功能障碍被认为是由于遗传学，炎症,和自身免疫。研究表明，氧化应激在触发这些条件中起着重要作用。目前,有几个标志表明血液炎症和氧化应激。本研究旨在探讨白癜风患者炎症和氧化应激指标的现状。方法本研究纳入白癜风患者和年龄性别匹配的健康对照。C反应蛋白(CRP),中性粒细胞与淋巴细胞比率（NLR），单核细胞与淋巴细胞比率（MLR），血小板与淋巴细胞比率（PLR），计算并比较单核细胞与高密度脂蛋白比值（MHR）和白癜风的程度。结果该研究包括138名参与者（69名白癜风和69名对照）。平均为41.46岁，女性占主导地位（55.1％）。患者组表现出更高水平的血小板，中性粒细胞，CRP,NLR,MLR,PLR,与对照组相比，淋巴细胞和HDL的水平较低（p>0.05）。组间唯一显著不同的值是MHR(p=0.03)。泛发性白癜风组表现出更高水平的血小板，中性粒细胞，单核细胞,CRP,NLR,PLR,还有MLR,与局部组相比，淋巴细胞和HDL水平较低。组间唯一显著不同的值是MHR和MLR(p=0.02,p=0.03)。结论本研究发现白癜风患者MHR和CRP值均较高。此外,全身型白癜风患者的MHR和MLR值较高。这些结果表明，MHR是白癜风全身性炎症和氧化应激的可靠指标。
