PDF(Pubmed)
Abstract：
UNASSIGNED: In the spectrum of Alzheimer\'s Disease (AD) and related disorders, the resting-state functional magnetic resonance imaging (rs-fMRI) signals within the cerebral cortex may exhibit distinct characteristics across various frequency ranges. Nevertheless, this hypothesis has not yet been substantiated within the broader context of whole-brain functional connectivity. This study aims to explore potential modifications in degree centrality (DC) and voxel-mirrored homotopic connectivity (VMHC) among individuals with amnestic mild cognitive impairment (aMCI) and AD, while assessing whether these alterations differ across distinct frequency bands.
UNASSIGNED: This investigation encompassed a total of 53 AD patients, 40 aMCI patients, and 40 healthy controls (HCs). DC and VMHC values were computed within three distinct frequency bands: classical (0.01-0.08 Hz), slow-4 (0.027-0.073 Hz), and slow-5 (0.01-0.027 Hz) for the three respective groups. To discern differences among these groups, ANOVA and subsequent post hoc two-sample t-tests were employed. Cognitive function assessment utilized the mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA). Pearson correlation analysis was applied to investigate the associations between MMSE and MoCA scores with DC and VMHC.
UNASSIGNED: Significant variations in degree centrality (DC) were observed among different groups across diverse frequency bands. The most notable differences were identified in the bilateral caudate nucleus (CN), bilateral medial superior frontal gyrus (mSFG), bilateral Lobule VIII of the cerebellar hemisphere (Lobule VIII), left precuneus (PCu), right Lobule VI of the cerebellar hemisphere (Lobule VI), and right Lobule IV and V of the cerebellar hemisphere (Lobule IV, V). Likewise, disparities in voxel-mirrored homotopic connectivity (VMHC) among groups were predominantly localized to the posterior cingulate gyrus (PCG) and Crus II of the cerebellar hemisphere (Crus II). Across the three frequency bands, the brain regions exhibiting significant differences in various parameters were most abundant in the slow-5 frequency band.
UNASSIGNED: This study enhances our understanding of the pathological and physiological mechanisms associated with AD continuum. Moreover, it underscores the importance of researchers considering various frequency bands in their investigations of brain function.
UNASSIGNED: This investigation encompassed a total of 53 AD patients, 40 aMCI patients, and 40 healthy controls (HCs). DC and VMHC values were computed within three distinct frequency bands: classical (0.01-0.08 Hz), slow-4 (0.027-0.073 Hz), and slow-5 (0.01-0.027 Hz) for the three respective groups. To discern differences among these groups, ANOVA and subsequent post hoc two-sample t-tests were employed. Cognitive function assessment utilized the mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA). Pearson correlation analysis was applied to investigate the associations between MMSE and MoCA scores with DC and VMHC.
UNASSIGNED: Significant variations in degree centrality (DC) were observed among different groups across diverse frequency bands. The most notable differences were identified in the bilateral caudate nucleus (CN), bilateral medial superior frontal gyrus (mSFG), bilateral Lobule VIII of the cerebellar hemisphere (Lobule VIII), left precuneus (PCu), right Lobule VI of the cerebellar hemisphere (Lobule VI), and right Lobule IV and V of the cerebellar hemisphere (Lobule IV, V). Likewise, disparities in voxel-mirrored homotopic connectivity (VMHC) among groups were predominantly localized to the posterior cingulate gyrus (PCG) and Crus II of the cerebellar hemisphere (Crus II). Across the three frequency bands, the brain regions exhibiting significant differences in various parameters were most abundant in the slow-5 frequency band.
UNASSIGNED: This study enhances our understanding of the pathological and physiological mechanisms associated with AD continuum. Moreover, it underscores the importance of researchers considering various frequency bands in their investigations of brain function.
摘要：
■在阿尔茨海默病（AD）和相关疾病的范围内，大脑皮层内的静息态功能磁共振成像(rs-fMRI)信号在不同频率范围内可能表现出不同的特征.然而，这一假设尚未在全脑功能连接的更广泛背景下得到证实.本研究旨在探索遗忘型轻度认知障碍（aMCI）和AD患者的度数中心性（DC）和体素镜像同源连接（VMHC）的潜在改变。同时评估这些改变是否在不同的频带上有所不同。
■这项调查共包括53名AD患者，40名aMCI患者，和40个健康对照（HCs）。DC和VMHC值在三个不同的频带内计算：经典（0.01-0.08Hz），slow-4(0.027-0.073Hz),和slow-5（0.01-0.027Hz）分别为三组。为了辨别这些群体之间的差异，采用方差分析和随后的事后双样本t检验。认知功能评估采用小型精神状态检查（MMSE）和蒙特利尔认知评估（MoCA）。应用Pearson相关分析探讨MMSE和MoCA评分与DC和VMHC的相关性。
■在不同频带的不同组之间观察到程度中心性(DC)的显著变化。在双侧尾状核（CN）中发现了最明显的差异，双侧内侧额上回（mSFG），小脑半球的双侧小叶VIII（小叶VIII），左前肌(PCu)，小脑半球的右小叶VI（小叶VI），和小脑半球的右小叶IV和V（小叶IV，V).同样，组间体素镜像同位连接（VMHC）的差异主要位于后扣带回（PCG）和小脑半球的CrusII（CrusII）。在三个频带中，在慢速5频段中，在各种参数上表现出显着差异的大脑区域最为丰富。
■这项研究增强了我们对与AD连续体相关的病理和生理机制的理解。此外，它强调了研究人员在研究大脑功能时考虑各种频段的重要性。
■这项调查共包括53名AD患者，40名aMCI患者，和40个健康对照（HCs）。DC和VMHC值在三个不同的频带内计算：经典（0.01-0.08Hz），slow-4(0.027-0.073Hz),和slow-5（0.01-0.027Hz）分别为三组。为了辨别这些群体之间的差异，采用方差分析和随后的事后双样本t检验。认知功能评估采用小型精神状态检查（MMSE）和蒙特利尔认知评估（MoCA）。应用Pearson相关分析探讨MMSE和MoCA评分与DC和VMHC的相关性。
■在不同频带的不同组之间观察到程度中心性(DC)的显著变化。在双侧尾状核（CN）中发现了最明显的差异，双侧内侧额上回（mSFG），小脑半球的双侧小叶VIII（小叶VIII），左前肌(PCu)，小脑半球的右小叶VI（小叶VI），和小脑半球的右小叶IV和V（小叶IV，V).同样，组间体素镜像同位连接（VMHC）的差异主要位于后扣带回（PCG）和小脑半球的CrusII（CrusII）。在三个频带中，在慢速5频段中，在各种参数上表现出显着差异的大脑区域最为丰富。
■这项研究增强了我们对与AD连续体相关的病理和生理机制的理解。此外，它强调了研究人员在研究大脑功能时考虑各种频段的重要性。
