PDF(Pubmed)
Abstract：
Cronkhite-Canada syndrome is a rare gastrointestinal polyposis syndrome with distinctive clinical features and endoscopic findings. Diagnosis can be challenging without suspicion, and the disease carries high mortality due to complications such as infection, gastrointestinal bleeding, and malignancies. This paper presents two cases of Cronkhite-Canada syndrome occurring after coronavirus disease 2019 (COVID-19) mRNA vaccination. Both cases exhibited typical clinical findings, including hypogeusia, onychodystrophy, alopecia, and weight loss. Typical polyposis in the gastrointestinal tract was confirmed through endoscopies. As symptomatic treatment did not improve the symptoms, corticosteroids were administered, and symptoms and laboratory test results improved immediately. The patients improved upon corticosteroids tapering. These cases illustrate typical presentations of Cronkhite-Canada syndrome and the course of the disease following corticosteroid treatment. Additionally, they suggest the possibility that Cronkhite-Canada syndrome may be triggered by COVID-19 mRNA vaccination.
摘要：
Cronkhite-Canada综合征是一种罕见的胃肠道息肉病综合征，具有独特的临床特征和内窥镜检查结果。没有怀疑的诊断可能具有挑战性，由于感染等并发症，这种疾病死亡率很高，消化道出血,和恶性肿瘤。本文介绍了2019年冠状病毒病（COVID-19）mRNA疫苗接种后发生的两例Cronkhite-Canada综合征。两例均表现出典型的临床表现，包括伪善,甲营养不良,脱发,和减肥。通过内窥镜检查证实了胃肠道中的典型息肉病。由于对症治疗并没有改善症状，使用皮质类固醇，症状和实验室检查结果立即改善。皮质类固醇逐渐减少后，患者有所改善。这些病例说明了Cronkhite-Canada综合征的典型表现以及皮质类固醇治疗后的病程。此外,他们认为Cronkhite-Canada综合征可能是由COVID-19mRNA疫苗引发的。
