Abstract：
Pregabalin is an anti-epileptic drug approved for the treatment of neuropathic pain and focal-onset seizures. In a few cases, pregabalin was associated with parkinsonism. We present a case of a 48-year-old female who had hypertension and was on losartan 50 mg/daily. Her general practitioner prescribed pregabalin 150 mg/daily for fibromyalgia-related pain. The subject doubled the dosage without medical advice. After 5 days of the increased dosage, she started to experience difficulty and slowness in movement associated with resting tremors. Neuroimaging, electrodiagnostic studies, and laboratory exams were unremarkable. Secondary parkinsonism was suspected, so pregabalin was discontinued. The subject fully recovered within 7 days. To the authors\' knowledge, only 6 cases of pregabalin-induced parkinsonism were reported in the literature. Pregabalin discontinuation was the most common management. All individuals fully recovered after pregabalin withdrawal. The mechanism of pregabalin-induced parkinsonism is not fully understood.
摘要：
普瑞巴林是一种被批准用于治疗神经性疼痛和局灶性发作性癫痫发作的抗癫痫药物。在少数情况下,普瑞巴林与帕金森病有关.我们介绍了一例48岁女性，患有高血压，每天服用50mg氯沙坦。她的全科医生处方普瑞巴林150毫克/天用于纤维肌痛相关的疼痛。受试者在没有医疗建议的情况下将剂量加倍。增加剂量5天后，她开始经历与休息性震颤相关的运动困难和缓慢。神经影像学,电诊断研究，实验室考试并不引人注目。怀疑是继发性帕金森病,所以普瑞巴林被停用了.受试者在7天内完全康复。就作者所知，文献中仅报道了6例普瑞巴林诱发的帕金森病.普瑞巴林停药是最常见的治疗方法。所有个体在普瑞巴林停药后完全康复。普瑞巴林诱导的帕金森病的机制尚不完全清楚。
