PDF(Pubmed)
Abstract：
The oral cavity harbors complex communities comprising bacteria, archaea, fungi, protozoa, and viruses. The oral microbiota is establish at birth and develops further during childhood, with early life factors such as birth mode, feeding practices, and oral hygiene, reported to influence this development and the susceptibility to caries. We here analyzed the oral bacterial composition in saliva of 260 Swedish children at two, three and five years of age using 16S rRNA gene profiling to examine its relation to environmental factors and caries development at five years of age. We were able to assign the salivary bacterial community in each child at each time point to one of seven distinct clusters. We observed an individual dynamic in the development of the oral microbiota related to early life factors, such as being first born, born by C-section, maternal perinatal antibiotics use, with a distinct transition between three and five years of age. Different bacterial signatures depending on age were related to increased caries risk, while Peptococcus consistently linked to reduced risk of caries development.
摘要：
口腔有复杂的群落，包括细菌，古细菌,真菌,原生动物,和病毒。口腔微生物群在出生时建立，并在儿童期进一步发展，与早期生活因素，如出生模式，喂养实践，口腔卫生，据报道会影响这种发展和龋齿的易感性。我们在这里分析了260名瑞典儿童的唾液中的口腔细菌成分，3岁和5岁时使用16SrRNA基因谱分析检查其与环境因素和5岁时龋齿发展的关系。我们能够在每个时间点将每个孩子的唾液细菌群落分配到七个不同的簇之一。我们观察到与早期生命因素相关的口腔微生物群发育的个体动态，比如第一次出生，剖腹产出生，产妇围产期抗生素的使用，在三到五岁之间有明显的过渡。不同年龄的细菌特征与龋齿风险增加有关，而肽球菌始终与降低龋齿发展的风险有关。
