PDF(Pubmed)
Abstract：
Computational fluid dynamics (CFD) has been utilized to calculate hemodynamic parameters in anterior communicating artery aneurysm (AComA), which is located at a junction between left and right A1 and A2 segments. However, complete or half circle of Willis (CoW) models are used indiscriminately. This study aims to suggest recommendations for determining suitable CoW model. Five patient-specific CoW models with AComA were used, and each model was divided into complete, left-half, and right-half models. After validating the CFD using a flow experiment, the hemodynamic parameters and flow patterns in five AComAs were compared. In four out of five cases, inflow from one A1 side had a dominant influence on the AComA, while both left and right A1 sides affected the AComA in the remaining case. Also, the average difference in time-averaged wall shear stress between the complete and half models for four cases was 4.6%, but it was 62% in the other case. The differences in the vascular resistances of left and right A1 and A2 segments greatly influenced the flow patterns in the AComA. These results may help to enhance clinicians\' understanding of blood flow in the brain, leading to improvements in diagnosis and treatment of cerebral aneurysms.
摘要：
计算流体动力学（CFD）已用于计算前交通动脉瘤（AComA）的血液动力学参数，其位于左A1和右A1和A2段之间的接合处。然而,全圆或半圆的威利斯(CoW)模型不加区别地使用。本研究旨在为确定合适的CoW模型提出建议。使用了五种具有AComA的患者特异性CoW模型，每个模型都被分为完整的，左半,和右半模型。使用流动实验验证CFD后，比较了五种AComAs的血流动力学参数和血流模式。在五个案例中的四个,A1一侧的流入对AComA有主要影响，而左侧和右侧A1在其余情况下影响了AComA。此外，四个案例的完整模型和半模型之间的时间平均壁剪应力的平均差异为4.6％，但在另一种情况下是62%。左，右A1和A2段的血管阻力差异极大地影响了AComA中的流动模式。这些结果可能有助于提高临床医生对大脑血流的理解，改善脑动脉瘤的诊断和治疗。
