PDF(Pubmed)
Abstract：
Many areas of science and medicine would benefit from selective release of drugs in specific regions. Nanoparticle drug carriers activated by focused ultrasound-remotely applied, depth-penetrating energy-may provide such selective interventions. Here, we developed stable, ultrasound-responsive nanoparticles that can be used to release drugs effectively and safely in non-human primates. The nanoparticles were used to release propofol in deep brain visual regions. The release reversibly modulated the subjects\' visual choice behavior and was specific to the targeted region and to the released drug. Gadolinium-enhanced MR imaging suggested an intact blood-brain barrier. Blood draws showed normal clinical chemistry and hematology. In summary, this study provides a safe and effective approach to release drugs on demand in selected deep brain regions at levels sufficient to modulate behavior.
摘要：
许多科学和医学领域将受益于药物在特定感兴趣区域的选择性释放。通过聚焦超声远程应用激活的纳米颗粒药物载体，深度穿透能量可以提供这样的选择性干预。这里,我们发展稳定，可用于在非人灵长类动物中有效和安全地释放药物的超声响应纳米颗粒。纳米颗粒用于在脑深部视觉区域释放丙泊酚。释放可逆地调节受试者的视觉选择行为，并且对目标区域和释放的药物具有特异性。GadoliniumMRI增强成像提示血脑屏障完整。抽血显示正常的临床化学和血液学。总之,这项研究提供了一种安全有效的方法，可以在选定的大脑深部区域按需释放足以调节行为的药物。
