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Abstract：
This narrative review aims to demonstrate and summarize the complex relationship between Ehlers-Danlos syndromes (EDS) and temporomandibular disorders (TMD) by reviewing the results of observational studies and case reports. EDS are a set of hereditary connective tissue disorders, where generalized joint hypermobility (GJH), especially in the hypermobile subtype (hEDS), is a key symptom. Mutations have been identified in genes that impact the production or assembly of collagen for all subtypes except hEDS. While the correlation between GJH and TMD has been analysed in various studies, fewer studies have examined TMD in patients with EDS, with most showing an increased prevalence of TMD. In case-control studies, an elevated prevalence of myalgia, arthralgia and disc-related disorders was found in individuals with EDS. Various therapeutic interventions have been reported within the literature in the form of case reports and observational studies, but there are no long-term clinical trials with results on the efficacy of different therapeutic approaches to date. This review demonstrates the high prevalence of different TMDs in different subtypes of EDS, but also shows that little is known about the success of treatment thus far. Further clinical research is necessary to provide adequate guidance on targeted treatment.
摘要：
这篇叙述性综述旨在通过回顾观察性研究和病例报告的结果来证明和总结Ehlers-Danlos综合征（EDS）与颞下颌关节紊乱病（TMD）之间的复杂关系。EDS是一组遗传性结缔组织疾病，其中广义关节过度活动(GJH)，特别是在超移动亚型(HEDS)中，是一个关键的症状。已经在影响除hEDS以外的所有亚型的胶原的产生或组装的基因中鉴定了突变。虽然在各种研究中已经分析了GJH和TMD之间的相关性，很少有研究检查EDS患者的TMD，大多数显示TMD患病率增加。在病例对照研究中，肌痛的患病率升高，在EDS患者中发现关节痛和椎间盘相关疾病。文献中以病例报告和观察性研究的形式报道了各种治疗干预措施，但迄今为止，还没有关于不同治疗方法疗效的长期临床试验结果。这篇综述证明了不同亚型EDS中不同TMD的高患病率，但也表明，到目前为止，人们对治疗的成功知之甚少。需要进一步的临床研究为针对性治疗提供足够的指导。
