PDF(Pubmed)
Abstract：
Bladder cancer is one of the most frequent malignant tumors of the urinary system. The prevalence of bladder cancer among men and women is roughly 5:2, and both its incidence and death have been rising steadily over the past few years. At the moment, metastasis and recurrence of advanced bladder cancer-which are believed to be connected to the malfunction of multigene and multilevel cell signaling network-remain the leading causes of bladder cancer-related death. The therapeutic treatment of bladder cancer will be greatly aided by the elucidation of these mechanisms. New concepts for the treatment of bladder cancer have been made possible by the advancement of research technologies and a number of new treatment options, including immunotherapy and targeted therapy. In this paper, we will extensively review the development of the tumor microenvironment and the possible molecular mechanisms of bladder cancer.
摘要：
膀胱癌是泌尿系统最常见的恶性肿瘤之一。男性和女性膀胱癌的患病率约为5：2，并且其发病率和死亡率在过去几年中一直在稳步上升。此刻,晚期膀胱癌的转移和复发-被认为与多基因和多水平细胞信号传导网络故障有关-仍然是膀胱癌相关死亡的主要原因。这些机制的阐明将大大有助于膀胱癌的治疗。研究技术的进步和许多新的治疗方案使膀胱癌的治疗新概念成为可能,包括免疫治疗和靶向治疗。在本文中,我们将广泛回顾肿瘤微环境的发展以及膀胱癌可能的分子机制。
