Abstract：
Both cutaneous radiation injury and radiation combined injury (RCI) could have serious skin traumas, which are collectively referred to as radiation-associated skin injuries in this paper. These two types of skin injuries require special managements of wounds, and the therapeutic effects still need to be further improved. Cutaneous radiation injuries are common in both radiotherapy patients and victims of radioactive source accidents, which could lead to skin necrosis and ulcers in serious conditions. At present, there are still many challenges in management of cutaneous radiation injuries including early diagnosis, lesion assessment, and treatment prognosis. Radiation combined injuries are special and important issues in severe nuclear accidents, which often accompanied by serious skin traumas. Mass victims of RCI would be the focus of public health concern. Three-dimensional (3D) bioprinting, as a versatile and favourable technique, offers effective approaches to fabricate biomimetic architectures with bioactivity, which provides potentials for resolve the challenges in treating radiation-associated skin injuries. Combining with the cutting-edge advances in 3D skin bioprinting, the authors analyse the damage characteristics of skin wounds in both cutaneous radiation injury and RCI and look forward to the potential value of 3D skin bioprinting for the treatments of radiation-associated skin injuries.
摘要：
皮肤辐射损伤和辐射复合损伤（RCI）都可能有严重的皮肤创伤，本文统称为辐射相关皮肤损伤。这两种类型的皮肤损伤需要对伤口进行特殊处理，治疗效果仍需进一步提高。皮肤辐射损伤在放射治疗患者和放射源事故的受害者中都很常见，在严重的情况下可能导致皮肤坏死和溃疡。目前,在皮肤放射损伤的管理方面仍然存在许多挑战，包括早期诊断，病变评估,和治疗预后。辐射复合伤是严重核事故中的特殊和重要问题,常伴有严重的皮肤创伤。RCI的大量受害者将是公共卫生关注的焦点。三维（3D）生物打印，作为一种多功能和有利的技术，提供了制造具有生物活性的仿生结构的有效方法，这为解决治疗辐射相关皮肤损伤的挑战提供了潜力。结合3D皮肤生物打印的前沿进展，作者分析了皮肤放射性损伤和RCI中皮肤创伤的损伤特征，并展望了3D皮肤生物打印技术在放射性皮肤损伤治疗中的潜在价值。
