PDF(Pubmed)
Abstract：
Hypervirulent Klebsiella pneumoniae remains a significant global public health concern, characterized by a unique syndrome involving monomicrobial primary pyogenic liver abscesses, often leading to metastatic complications such as endophthalmitis, meningitis, and other infections. These infections are frequently observed in immunocompetent hosts or diabetic patients, particularly those of Asian ethnicity. In this report, we present the case of a 66-year-old Burmese female, currently residing in the United States, who presented with severe swelling, pain, discharge, and vision loss in her left eye, along with abdominal pain. Subsequent investigation revealed monomicrobial Klebsiella pneumoniae acute cholecystitis with an adjacent liver abscess, complicated by bacteremia, endogenous endophthalmitis, and portal vein thrombosis. Treatment with ceftriaxone proved successful in addressing her intra-abdominal infections, while anticoagulation therapy was initiated following multidisciplinary discussions among all involved subspecialties. Early diagnosis and the timely administration of appropriate treatment are crucial in reducing mortality and preventing further complications.
摘要：
高毒力肺炎克雷伯菌仍然是一个重要的全球公共卫生问题。其特征是涉及单一抗菌原发性化脓性肝脓肿的独特综合征，常导致转移性并发症，如眼内炎，脑膜炎,和其他感染。这些感染经常在有免疫能力的宿主或糖尿病患者中观察到，尤其是亚洲种族。在这份报告中,我们介绍了一个66岁的缅甸女性的案例，目前居住在美国,出现严重肿胀的人，疼痛,放电,左眼视力下降,还有腹痛.随后的调查显示，具有邻近肝脓肿的肺炎克雷伯菌急性胆囊炎，并发菌血症,内源性眼内炎，门静脉血栓形成.头孢曲松治疗成功解决了她的腹腔感染，而抗凝治疗是在所有涉及的亚专科进行多学科讨论后开始的.早期诊断和及时给予适当的治疗对于降低死亡率和预防进一步的并发症至关重要。
