关键词: Case report Liposarcoma Liposarcoma hepático pleomorfo MDM2 Pleomorphic hepatic liposarcoma Presentación de un caso clínico p16 p53

Mesh : Humans Male Adult Proto-Oncogene Proteins c-mdm2 / genetics Liposarcoma / pathology Adipocytes / pathology

来  源:   DOI:10.1016/j.patol.2023.10.003

Abstract:
Primary hepatic liposarcoma is an extremely rare malignant tumour derived from adipocytes and is part of the group of mesenchymal tumours. We present the case of a 43-year-old Hispanic male patient with a pleomorphic hepatic liposarcoma and absence of MDM2 gene amplification. Two years and six months after surgery, the patient is asymptomatic. The present case is the first report of this entity with positive immunohistochemical testing for p16, p53, S100, vimentin and absence of MDM2 gene amplification.
摘要:
原发性肝脂肪肉瘤是一种极其罕见的源自脂肪细胞的恶性肿瘤,是间质肿瘤组的一部分。我们介绍了一名43岁的西班牙裔男性患者,患有多形性肝脂肪肉瘤且没有MDM2基因扩增。手术后两年六个月,患者无症状。本病例是该实体的第一份报告,其p16,p53,S100,波形蛋白的免疫组织化学检测呈阳性,并且没有MDM2基因扩增。
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