Abstract：
Plants used in traditional medicine offer an affordable new alternative in tissue repair therapy. This study aimed to evaluate the effectiveness of the 5% Rhizophora mangle cream compared to the 5% dexpanthenol cream in healing open surgical wounds on the upper eyelid. A total of 18 patients were submitted to the experiment and divided into 2 groups with 9 patients each who used topically and daily 5% dexpanthenol cream (control group) or 5% R.mangle cream (intervention group) for 7 days. Clinical, morphometric and histomorphometric analyses of wounds and surgical procedures for skin removal were performed. In the morphometric analysis, all wounds treated with R.mangle and dexpanthenol creams showed complete macroscopic scars, without inflammatory signs and infection free. The skin hydration values in pre and post application periods of the cream were 43.82 ± 43.93 and 62.12 ± 67.40 respectively. The histomorphometric study showed lower values of epithelium distance in R. mangle group and higher in dexpanthenol group with significant difference between groups (p < 0.05). The R.mangle 5% cream proved to be effective in healing wounds of human upper eyelid skin with a significant improvement in epithelization compared to dexpanthenol 5% cream.
摘要：
传统医学中使用的植物为组织修复疗法提供了一种负担得起的新选择。这项研究旨在评估与5％右泛醇乳膏相比，5％根霉乳膏在上眼睑开放性手术伤口愈合中的有效性。共有18名患者接受了实验，并分为2组，每组9名患者，他们每天局部使用5％右泛醇乳膏（对照组）或5％R.mangle乳膏（干预组），为期7天。临床,进行了伤口的形态计量学和组织形态计量学分析以及皮肤去除的外科手术。在形态测量分析中,用R.mangle和右泛醇乳膏治疗的所有伤口均显示出完全的宏观疤痕，无炎症体征和无感染。乳膏施用前和施用后的皮肤水合值分别为43.82±43.93和62.12±67.40。组织形态学研究显示，R.mangle组上皮距离值较低，右泛醇组上皮距离值较高，组间差异有统计学意义（p<0.05）。与右泛醇5%乳膏相比,R.mangle5%乳膏被证明在人上眼睑皮肤的伤口愈合中有效,上皮形成显著改善。
