Abstract：
Schizophrenia (SCZ) is a complex neuropsychiatric disorder widely recognized for its impaired bioenergy utilization. The astrocyte-neuron lactate shuttle (ANLS) plays a critical role in brain energy supply. Recent studies have revealed abnormal lactate metabolism in SCZ, which is associated with mitochondrial dysfunction, tissue hypoxia, gastric acid retention, oxidative stress, neuroinflammation, abnormal brain iron metabolism, cerebral white matter hypermetabolic activity, and genetic susceptibility. Furthermore, astrocytes, neurons, and glutamate abnormalities are prevalent in SCZ with abnormal lactate metabolism, which are essential components for maintaining ANLS in the brain. Therefore, an in-depth study of the pathophysiological mechanisms of ANLS in SCZ with abnormal lactate metabolism will contribute to a better understanding of the pathogenesis of SCZ and provide new ideas and approaches for the diagnosis and treatment of SCZ.
摘要：
精神分裂症（SCZ）是一种复杂的神经精神疾病，因其生物能量利用受损而被广泛认可。星形胶质细胞-神经元乳酸穿梭（ANLS）在大脑能量供应中起着至关重要的作用。最近的研究表明SCZ中的乳酸代谢异常，这与线粒体功能障碍有关，组织缺氧，胃酸潴留,氧化应激，神经炎症，大脑铁代谢异常，脑白质高代谢活动，和遗传易感性。此外，星形胶质细胞,神经元，谷氨酸异常在乳酸代谢异常的SCZ中普遍存在，是维持大脑ANLS的重要组成部分。因此,深入研究乳酸代谢异常的SCZ中ANLS的病理生理机制,将有助于更好地了解SCZ的发病机制,为SCZ的诊断和治疗提供新的思路和途径。
