PDF(Pubmed)
Abstract：
UNASSIGNED: Early-onset diabetes appears to be an aggressive phenotype of type 2 diabetes (T2D). The impact of the age of onset of T2D on albuminuria, especially high urinary albumin excretion, remains to be investigated.
UNASSIGNED: To determine whether adults diagnosed with T2D between the ages of 18 and 45 more aggressively develop albuminuria.
UNASSIGNED: Conducted at Taizhou People\'s Hospital from November 2018 to August 2020, this cross-sectional study enrolled T2D patients. Anthropometric measures, metabolic profiles, and urinary albumin creatinine ratio were examined. Patients were categorized into early-onset (≤45 years) and late-onset (> 45 years) groups. Univariate and multivariate analyses were performed to identify albuminuria risk factors. Subgroups were formed based on age at diabetes diagnosis and gender. Multivariate ordinal logistic regression analysis was then conducted to identify distinct risk factors within each subgroup.
UNASSIGNED: Analyzing 1900 T2D patients, it was found significantly higher albuminuria prevalence in early-onset patients (35.08% vs 29.92%, P = 0.022). The risk of albuminuria in early-onset patients was 1.509 times higher than that in late-onset patients, especially among male patients, where the risk increased to 1.980. For late-onset patients, disease duration and glycated hemoglobin (HbA1c) were identified as risk factors, whereas for early-onset patients, body-mass index (BMI) and systolic blood pressure were associated with increased risk. Among male patients, age at diagnosis of diabetes, blood pressure, and BMI were identified as risk factors, while for female patients, disease duration and HbA1c played a significant role. Additionally, high-density lipoprotein cholesterol was found to be a protective factor against albuminuria.
UNASSIGNED: Individuals diagnosed with T2D before 45 face heightened albuminuria risk, especially males. Risk factors vary by gender and onset age, highlighting the need for tailored management strategies.
UNASSIGNED: To determine whether adults diagnosed with T2D between the ages of 18 and 45 more aggressively develop albuminuria.
UNASSIGNED: Conducted at Taizhou People\'s Hospital from November 2018 to August 2020, this cross-sectional study enrolled T2D patients. Anthropometric measures, metabolic profiles, and urinary albumin creatinine ratio were examined. Patients were categorized into early-onset (≤45 years) and late-onset (> 45 years) groups. Univariate and multivariate analyses were performed to identify albuminuria risk factors. Subgroups were formed based on age at diabetes diagnosis and gender. Multivariate ordinal logistic regression analysis was then conducted to identify distinct risk factors within each subgroup.
UNASSIGNED: Analyzing 1900 T2D patients, it was found significantly higher albuminuria prevalence in early-onset patients (35.08% vs 29.92%, P = 0.022). The risk of albuminuria in early-onset patients was 1.509 times higher than that in late-onset patients, especially among male patients, where the risk increased to 1.980. For late-onset patients, disease duration and glycated hemoglobin (HbA1c) were identified as risk factors, whereas for early-onset patients, body-mass index (BMI) and systolic blood pressure were associated with increased risk. Among male patients, age at diagnosis of diabetes, blood pressure, and BMI were identified as risk factors, while for female patients, disease duration and HbA1c played a significant role. Additionally, high-density lipoprotein cholesterol was found to be a protective factor against albuminuria.
UNASSIGNED: Individuals diagnosed with T2D before 45 face heightened albuminuria risk, especially males. Risk factors vary by gender and onset age, highlighting the need for tailored management strategies.
摘要：
■早发性糖尿病似乎是2型糖尿病（T2D）的侵袭性表型。T2D发病年龄对蛋白尿的影响，尤其是高尿白蛋白排泄,还有待调查。
■确定18至45岁之间诊断为T2D的成年人是否更积极地发展为蛋白尿。
■于2018年11月至2020年8月在台州市人民医院开展，本横断面研究纳入T2D患者。人体测量,代谢概况，并检查尿白蛋白肌酐比值。患者分为早发型（≤45岁）和晚发型（>45岁）组。进行单因素和多因素分析以确定蛋白尿的危险因素。根据糖尿病诊断时的年龄和性别形成亚组。然后进行多因素有序logistic回归分析，以确定每个亚组中不同的危险因素。
■分析1900名T2D患者，发现早发性患者的白蛋白尿患病率显着升高（35.08％vs29.92％，P=0.022)。早发型患者出现白蛋白尿的风险是晚发型患者的1.509倍,尤其是男性患者，其中风险增加到1.980。对于迟发性患者，疾病持续时间和糖化血红蛋白（HbA1c）被确定为危险因素，而对于早发型患者，体重指数(BMI)和收缩压与风险增加相关.在男性患者中，诊断为糖尿病的年龄，血压,BMI被确定为危险因素，而对于女性患者来说，病程和HbA1c起了显著作用。此外,发现高密度脂蛋白胆固醇是抗蛋白尿的保护因素。
■在45岁之前诊断为T2D的个体面临升高的蛋白尿风险，尤其是男性。风险因素因性别和发病年龄而异，强调需要量身定制的管理策略。
■确定18至45岁之间诊断为T2D的成年人是否更积极地发展为蛋白尿。
■于2018年11月至2020年8月在台州市人民医院开展，本横断面研究纳入T2D患者。人体测量,代谢概况，并检查尿白蛋白肌酐比值。患者分为早发型（≤45岁）和晚发型（>45岁）组。进行单因素和多因素分析以确定蛋白尿的危险因素。根据糖尿病诊断时的年龄和性别形成亚组。然后进行多因素有序logistic回归分析，以确定每个亚组中不同的危险因素。
■分析1900名T2D患者，发现早发性患者的白蛋白尿患病率显着升高（35.08％vs29.92％，P=0.022)。早发型患者出现白蛋白尿的风险是晚发型患者的1.509倍,尤其是男性患者，其中风险增加到1.980。对于迟发性患者，疾病持续时间和糖化血红蛋白（HbA1c）被确定为危险因素，而对于早发型患者，体重指数(BMI)和收缩压与风险增加相关.在男性患者中，诊断为糖尿病的年龄，血压,BMI被确定为危险因素，而对于女性患者来说，病程和HbA1c起了显著作用。此外,发现高密度脂蛋白胆固醇是抗蛋白尿的保护因素。
■在45岁之前诊断为T2D的个体面临升高的蛋白尿风险，尤其是男性。风险因素因性别和发病年龄而异，强调需要量身定制的管理策略。
