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Abstract：
UNASSIGNED: To examine the correlation of neutrophil CD64 (nCD64) index with neurosyphilis (NS) across different stages of syphilis.
UNASSIGNED: A total of 1243 syphilis patients at different stages (344 of primary, 385 of secondary, and 514 of tertiary) included in this study were divided into NS and non-NS (NNS). Correlations of nCD64 index with currently used syphilis biomarkers were explored using Spearman correlation test. Relationships between nCD64 index and NS at different stages were investigated by stratified analysis and restricted cubic spline model. The diagnostic performance of nCD64 index for NS was assessed by receiver operating characteristic (ROC) curve.
UNASSIGNED: Significant statistical correlations of nCD64 index with cerebrospinal fluid (CSF) NS indicators were found in secondary and tertiary syphilis. Increased nCD64 index was associated with increased risk of NS in secondary and tertiary syphilis. ROC analysis values further confirmed the diagnostic potential of nCD64 index for NS. Marked decrease of nCD64 index was observed in NS patients after effective antisyphilitic treatments.
UNASSIGNED: The nCD64 index may help to the diagnosis of NS in secondary and tertiary syphilis.
UNASSIGNED: A total of 1243 syphilis patients at different stages (344 of primary, 385 of secondary, and 514 of tertiary) included in this study were divided into NS and non-NS (NNS). Correlations of nCD64 index with currently used syphilis biomarkers were explored using Spearman correlation test. Relationships between nCD64 index and NS at different stages were investigated by stratified analysis and restricted cubic spline model. The diagnostic performance of nCD64 index for NS was assessed by receiver operating characteristic (ROC) curve.
UNASSIGNED: Significant statistical correlations of nCD64 index with cerebrospinal fluid (CSF) NS indicators were found in secondary and tertiary syphilis. Increased nCD64 index was associated with increased risk of NS in secondary and tertiary syphilis. ROC analysis values further confirmed the diagnostic potential of nCD64 index for NS. Marked decrease of nCD64 index was observed in NS patients after effective antisyphilitic treatments.
UNASSIGNED: The nCD64 index may help to the diagnosis of NS in secondary and tertiary syphilis.
摘要：
■研究梅毒不同阶段中性粒细胞CD64（nCD64）指数与神经梅毒（NS）的相关性。
■共有1243名不同阶段的梅毒患者（原发性，385次，本研究中包含的514个三级）分为NS和非NS（NNS）。使用Spearman相关性检验探讨nCD64指数与目前使用的梅毒生物标志物的相关性。通过分层分析和有限三次样条模型研究了nCD64指数与不同阶段NS的关系。通过受试者工作特征（ROC）曲线评估nCD64指数对NS的诊断性能。
■在二级和三级梅毒中发现nCD64指数与脑脊液（CSF）NS指标的显着统计相关性。nCD64指数升高与二期和三期梅毒NS风险增加相关。ROC分析值进一步证实了nCD64指数对NS的诊断潜力。在有效的抗梅毒治疗后，NS患者中观察到nCD64指数显着下降。
■nCD64指数可能有助于诊断二期和三期梅毒中的NS。
■共有1243名不同阶段的梅毒患者（原发性，385次，本研究中包含的514个三级）分为NS和非NS（NNS）。使用Spearman相关性检验探讨nCD64指数与目前使用的梅毒生物标志物的相关性。通过分层分析和有限三次样条模型研究了nCD64指数与不同阶段NS的关系。通过受试者工作特征（ROC）曲线评估nCD64指数对NS的诊断性能。
■在二级和三级梅毒中发现nCD64指数与脑脊液（CSF）NS指标的显着统计相关性。nCD64指数升高与二期和三期梅毒NS风险增加相关。ROC分析值进一步证实了nCD64指数对NS的诊断潜力。在有效的抗梅毒治疗后，NS患者中观察到nCD64指数显着下降。
■nCD64指数可能有助于诊断二期和三期梅毒中的NS。
