UNASSIGNED: We describe three cases of pediatric medulloblastoma who developed t-MNs after receiving chemotherapy, including alkylating agents. Two of the patients had underlying genetic predisposition syndromes (TP53 pathologic variants). The latency period between initial diagnosis of medulloblastoma and the development of secondary cancer varied among the cases, ranging from 17 to 65 months. The three cases eventually succumbed from secondary malignancy, therapy-related complications and progression of primary disease, respectively.
UNASSIGNED: This report highlights the potential association between genetic predisposition syndromes and the development of therapy-related myeloid neoplasms in pediatric medulloblastoma survivors. It underscores the importance of surveillance for hematological abnormalities among such patients.
■我们描述了三例接受化疗后发展为t-MN的小儿髓母细胞瘤,包括烷化剂。其中两名患者具有潜在的遗传易感性综合征(TP53病理变异)。髓母细胞瘤的初始诊断和继发性癌症的发展之间的潜伏期在病例中有所不同。从17到65个月不等。三例最终死于继发性恶性肿瘤,治疗相关并发症和原发疾病进展,分别。
■本报告强调了遗传易感性综合征与儿童髓母细胞瘤幸存者治疗相关髓系肿瘤发展之间的潜在关联。它强调了监测此类患者中血液学异常的重要性。