PDF(Pubmed)
Abstract：
UNASSIGNED: Although immunization against coronavirus disease 2019 (COVID-19) is ongoing, adverse reactions to these vaccinations have been observed in isolated cases. We aimed to report different neurological complications developed after COVID-19 vaccination.
UNASSIGNED: In our case series study, we report all cases of CNS demyelination following COVID-19 immunization. Clinical evaluation, brain MRI, and CSF analysis for oligoclonal bands and IgG index were performed for all patients. Other investigations were performed for selected patients, including spine MRI, EEG, VEP, and aquaporin-4.
UNASSIGNED: Eighteen patients (eight males and ten females) with no history of COVID-19 infection had neurological manifestations (vertigo, ataxia, recurrent attacks of loss of consciousness, optic neuritis, and myelitis) starting within 14 days after Pfizer (n = 12) and AstraZeneca (n = 6) vaccination. MRI was obtained during the acute stage of the disease. The most common presenting symptoms were optic neuritis and hemiparesis. Sixteen patients had altered signal intensity and multiple variable-sized, round to ill-defined oval lesions suggestive of MS. Two showed findings compatible with transverse myelitis.
UNASSIGNED: This study identified CNS demyelination complications after COVID-19 vaccination. The COVID-19 vaccination could result in CNS complications, possibly connected to a post-vaccination inflammatory process. We recommend continuous post-marketing monitoring for adverse reactions in individuals who received the vaccines to establish a connection and guarantee the long-term safety of COVID-19 vaccines.
UNASSIGNED: In our case series study, we report all cases of CNS demyelination following COVID-19 immunization. Clinical evaluation, brain MRI, and CSF analysis for oligoclonal bands and IgG index were performed for all patients. Other investigations were performed for selected patients, including spine MRI, EEG, VEP, and aquaporin-4.
UNASSIGNED: Eighteen patients (eight males and ten females) with no history of COVID-19 infection had neurological manifestations (vertigo, ataxia, recurrent attacks of loss of consciousness, optic neuritis, and myelitis) starting within 14 days after Pfizer (n = 12) and AstraZeneca (n = 6) vaccination. MRI was obtained during the acute stage of the disease. The most common presenting symptoms were optic neuritis and hemiparesis. Sixteen patients had altered signal intensity and multiple variable-sized, round to ill-defined oval lesions suggestive of MS. Two showed findings compatible with transverse myelitis.
UNASSIGNED: This study identified CNS demyelination complications after COVID-19 vaccination. The COVID-19 vaccination could result in CNS complications, possibly connected to a post-vaccination inflammatory process. We recommend continuous post-marketing monitoring for adverse reactions in individuals who received the vaccines to establish a connection and guarantee the long-term safety of COVID-19 vaccines.
摘要：
■尽管2019年冠状病毒病（COVID-19）的免疫接种正在进行中，在个别病例中观察到这些疫苗接种的不良反应。我们旨在报告COVID-19疫苗接种后出现的不同神经系统并发症。
■在我们的案例系列研究中，我们报告了COVID-19免疫后所有中枢神经系统脱髓鞘的病例。临床评价,脑部MRI,对所有患者进行寡克隆条带和IgG指数的CSF分析。对选定的患者进行了其他调查，包括脊柱MRI,脑电图,VEP,和水通道蛋白-4.
■18例无COVID-19感染史的患者（8例男性，10例女性）有神经系统表现（眩晕，共济失调,反复发作的意识丧失,视神经炎,和脊髓炎）在辉瑞（n=12）和阿斯利康（n=6）接种疫苗后14天内开始。MRI是在疾病的急性期获得的。最常见的症状是视神经炎和偏瘫。16例患者的信号强度和多个可变大小，圆形至不明确的椭圆形病变提示MS。两个发现与横贯性脊髓炎相符。
■这项研究确定了COVID-19疫苗接种后中枢神经系统脱髓鞘并发症。COVID-19疫苗接种可能导致中枢神经系统并发症，可能与疫苗接种后的炎症过程有关。我们建议对接种疫苗的个人进行持续的上市后监测，以建立连接并确保COVID-19疫苗的长期安全。
■在我们的案例系列研究中，我们报告了COVID-19免疫后所有中枢神经系统脱髓鞘的病例。临床评价,脑部MRI,对所有患者进行寡克隆条带和IgG指数的CSF分析。对选定的患者进行了其他调查，包括脊柱MRI,脑电图,VEP,和水通道蛋白-4.
■18例无COVID-19感染史的患者（8例男性，10例女性）有神经系统表现（眩晕，共济失调,反复发作的意识丧失,视神经炎,和脊髓炎）在辉瑞（n=12）和阿斯利康（n=6）接种疫苗后14天内开始。MRI是在疾病的急性期获得的。最常见的症状是视神经炎和偏瘫。16例患者的信号强度和多个可变大小，圆形至不明确的椭圆形病变提示MS。两个发现与横贯性脊髓炎相符。
■这项研究确定了COVID-19疫苗接种后中枢神经系统脱髓鞘并发症。COVID-19疫苗接种可能导致中枢神经系统并发症，可能与疫苗接种后的炎症过程有关。我们建议对接种疫苗的个人进行持续的上市后监测，以建立连接并确保COVID-19疫苗的长期安全。
