PDF(Pubmed)
Abstract：
UNASSIGNED: Alteration in the various markers is seen in diabetic nephropathy (DN). In the current research, four different markers were evaluated and were examined for their diagnostic value in the nephropathic type 2 diabetes patients.
UNASSIGNED: A prospective clinical trial was piloted with diabetic male subjects with nephropathy. The subjects were followed up for 9 months. Thirty subjects were recruited as type 2 diabetes mellitus patients without nephropathy as controls. The interventional groups were grouped again as microalbuminuria, normoalbuminuria, and hyperfiltration. All of them underwent testing for urinary biomarkers like urine protein, ACR, HbA1C, and estimated glomerular filtration rate (eGFR). Correlation and logistic regression were used to compare all diagnostic tests across various groupings.
UNASSIGNED: The greatest area under curve (AUC) values were .90 and .91 for AGT and AGT/Cr, respectively. The AUC, specificity, sensitivity, and cut-off value of AGT/Cr were, respectively, .91, 85%, 91%, and 4.36 mg/g. When using urine as the cut-off, the sensitivity was 42 and 100 for ACR and eGFR both. All other biomarkers had lower values than the AGT. Less than. 50 was evident for NGAL/Cr and NAGL.
UNASSIGNED: To identify DN, before the initiation of the albuminuria, compared to other diagnostic markers, urinary AGT demonstrated a greater diagnostic value. Further research is suggested to corroborate the findings.
UNASSIGNED: A prospective clinical trial was piloted with diabetic male subjects with nephropathy. The subjects were followed up for 9 months. Thirty subjects were recruited as type 2 diabetes mellitus patients without nephropathy as controls. The interventional groups were grouped again as microalbuminuria, normoalbuminuria, and hyperfiltration. All of them underwent testing for urinary biomarkers like urine protein, ACR, HbA1C, and estimated glomerular filtration rate (eGFR). Correlation and logistic regression were used to compare all diagnostic tests across various groupings.
UNASSIGNED: The greatest area under curve (AUC) values were .90 and .91 for AGT and AGT/Cr, respectively. The AUC, specificity, sensitivity, and cut-off value of AGT/Cr were, respectively, .91, 85%, 91%, and 4.36 mg/g. When using urine as the cut-off, the sensitivity was 42 and 100 for ACR and eGFR both. All other biomarkers had lower values than the AGT. Less than. 50 was evident for NGAL/Cr and NAGL.
UNASSIGNED: To identify DN, before the initiation of the albuminuria, compared to other diagnostic markers, urinary AGT demonstrated a greater diagnostic value. Further research is suggested to corroborate the findings.
摘要：
■在糖尿病肾病(DN)中观察到各种标志物的改变。在目前的研究中,我们对4种不同的标志物进行了评估,并对其在肾病性2型糖尿病患者中的诊断价值进行了检查.
■一项前瞻性临床试验是针对患有肾病的糖尿病男性受试者进行的。受试者随访9个月。招募30名受试者作为无肾病的2型糖尿病患者作为对照。干预组再次分组为微量白蛋白尿,正常白蛋白尿,和超滤。他们都接受了尿蛋白等尿液生物标志物的检测，ACR,HbA1C,和估计的肾小球滤过率(eGFR)。相关性和逻辑回归用于比较不同组的所有诊断测试。
■AGT和AGT/Cr的最大曲线下面积（AUC）值分别为.90和.91，分别。AUC,特异性，灵敏度,AGT/Cr的截止值分别为，分别,.91，85%，91%,和4.36mg/g。当使用尿液作为切断时，ACR和eGFR的敏感性分别为42和100.所有其他生物标志物具有比AGT更低的值。小于。对于NGAL/Cr和NAGL,50是明显的。
■要识别DN，在白蛋白尿开始之前，与其他诊断标记相比，尿AGT表现出更高的诊断价值.建议进一步研究以证实这一发现。
■一项前瞻性临床试验是针对患有肾病的糖尿病男性受试者进行的。受试者随访9个月。招募30名受试者作为无肾病的2型糖尿病患者作为对照。干预组再次分组为微量白蛋白尿,正常白蛋白尿,和超滤。他们都接受了尿蛋白等尿液生物标志物的检测，ACR,HbA1C,和估计的肾小球滤过率(eGFR)。相关性和逻辑回归用于比较不同组的所有诊断测试。
■AGT和AGT/Cr的最大曲线下面积（AUC）值分别为.90和.91，分别。AUC,特异性，灵敏度,AGT/Cr的截止值分别为，分别,.91，85%，91%,和4.36mg/g。当使用尿液作为切断时，ACR和eGFR的敏感性分别为42和100.所有其他生物标志物具有比AGT更低的值。小于。对于NGAL/Cr和NAGL,50是明显的。
■要识别DN，在白蛋白尿开始之前，与其他诊断标记相比，尿AGT表现出更高的诊断价值.建议进一步研究以证实这一发现。
