Abstract：
OBJECTIVE: This study aimed to evaluate the effectiveness of a chitosan-based dressing (CD) in achieving early wound healing and hemostasis at palatal donor sites in patients undergoing free gingival graft (FGG) surgery.
METHODS: Thirty-two patients requiring FGG were treated in this randomized controlled clinical trial. Complete epithelialization (CE) and color match (CM) at donor sites were assessed by a blinded examiner on postoperative days 7, 14, 21, and 28. Donor sites were compressed for 2 min with wet gauze (WG) alone in control group (CG) or WG + CD in test group (TG) immediately after graft harvesting, and immediate bleeding (IB) was recorded (yes/no). Delayed bleeding (DB) (for 1 week), and number of analgesic tablets consumed, and VAS scores for pain (for 2 weeks) were recorded by patient every day.
RESULTS: Twenty-eight patients (14 in each group) were included in final analysis. The prevalence of CE (at weeks 2 and 3) and VAS scores for CM scores were higher in TG but the intergroup differences were statistically significant only for CM (at week 4). Number of patients exhibiting IB and DB was significantly fewer in the TG (p < .05). Although average pain scores and analgesic consumption were higher in TG up to 5 days, differences between two groups were not statistically significant at any time point.
CONCLUSIONS: Our data suggests that the application of CD increased re-epithelialization and accelerated wound healing process, although it did not reach statistical significance. Moreover, CD was found to significantly reduce bleeding complications, but it did not decrease the pain levels.
METHODS: Thirty-two patients requiring FGG were treated in this randomized controlled clinical trial. Complete epithelialization (CE) and color match (CM) at donor sites were assessed by a blinded examiner on postoperative days 7, 14, 21, and 28. Donor sites were compressed for 2 min with wet gauze (WG) alone in control group (CG) or WG + CD in test group (TG) immediately after graft harvesting, and immediate bleeding (IB) was recorded (yes/no). Delayed bleeding (DB) (for 1 week), and number of analgesic tablets consumed, and VAS scores for pain (for 2 weeks) were recorded by patient every day.
RESULTS: Twenty-eight patients (14 in each group) were included in final analysis. The prevalence of CE (at weeks 2 and 3) and VAS scores for CM scores were higher in TG but the intergroup differences were statistically significant only for CM (at week 4). Number of patients exhibiting IB and DB was significantly fewer in the TG (p < .05). Although average pain scores and analgesic consumption were higher in TG up to 5 days, differences between two groups were not statistically significant at any time point.
CONCLUSIONS: Our data suggests that the application of CD increased re-epithelialization and accelerated wound healing process, although it did not reach statistical significance. Moreover, CD was found to significantly reduce bleeding complications, but it did not decrease the pain levels.
摘要：
目的：本研究旨在评估壳聚糖基敷料（CD）在接受游离牙龈移植（FGG）手术的患者中，在腭供体部位实现早期伤口愈合和止血的有效性。
方法：本随机对照临床试验对32例需要FGG的患者进行了治疗。在术后第7、14、21和28天由盲检者评估供体部位的完全上皮化(CE)和颜色匹配(CM)。在移植物收获后立即在对照组（CG）中单独用湿纱布（WG）或在实验组（TG）中用湿纱布（WG）压缩供体部位2分钟，并记录即刻出血(IB)(是/否).延迟出血（DB）（1周），和消耗的止痛片数量，每天记录患者疼痛的VAS评分（持续2周）。
结果：28例患者（每组14例）纳入最终分析。TG中CE的患病率（第2周和第3周）和CM评分的VAS评分较高，但组间差异仅在CM（第4周）具有统计学意义。TG中显示IB和DB的患者数量明显较少（p<0.05）。虽然平均疼痛评分和止痛剂消耗量在TG最高达5天，两组在任何时间点的差异均无统计学意义.
结论：我们的数据表明，CD的应用增加了上皮的再形成和加速的伤口愈合过程，虽然没有达到统计学意义。此外，发现CD显著减少出血并发症，但它并没有降低疼痛程度。
方法：本随机对照临床试验对32例需要FGG的患者进行了治疗。在术后第7、14、21和28天由盲检者评估供体部位的完全上皮化(CE)和颜色匹配(CM)。在移植物收获后立即在对照组（CG）中单独用湿纱布（WG）或在实验组（TG）中用湿纱布（WG）压缩供体部位2分钟，并记录即刻出血(IB)(是/否).延迟出血（DB）（1周），和消耗的止痛片数量，每天记录患者疼痛的VAS评分（持续2周）。
结果：28例患者（每组14例）纳入最终分析。TG中CE的患病率（第2周和第3周）和CM评分的VAS评分较高，但组间差异仅在CM（第4周）具有统计学意义。TG中显示IB和DB的患者数量明显较少（p<0.05）。虽然平均疼痛评分和止痛剂消耗量在TG最高达5天，两组在任何时间点的差异均无统计学意义.
结论：我们的数据表明，CD的应用增加了上皮的再形成和加速的伤口愈合过程，虽然没有达到统计学意义。此外，发现CD显著减少出血并发症，但它并没有降低疼痛程度。
