Abstract：
METHODS: Although age at menopause has been linked to higher risk of physical frailty in later life, little is known about other reproductive factors.
OBJECTIVE: Our study aimed to investigate the associations between 1) age at menarche, 2) age at natural menopause, 3) duration of reproductive period, 4) number of children, 5) use of oral contraceptives (OCP), and 6) use of hormone replacement therapy (HRT) with the risk of physical frailty in late life.
METHODS: We used data from 5934 women of the Singapore Chinese Health Study who experienced natural menopause, and participated in the third follow-up interviews when physical frailty was assessed. Logistic regression was used to evaluate association of reproductive factors evaluated during baseline and prior follow-up interviews with physical frailty at follow-up 3.
METHODS: Community-dwelling Chinese women living in Singapore. Participants had a mean age of 52.6 years at baseline (1993-1998), and a mean age of 72.8 years during the third follow-up (2014-2017).
METHODS: Sociodemographic characteristics, level of education, smoking history, physical activity, and history of physician-diagnosed comorbidities were collected. Participants\' weight and height were self-reported. We used a modified Cardiovascular Health Study phenotype to assess physical frailty.
RESULTS: Age at menarche was inversely associated with the likelihood of physical frailty (Ptrend = 0.001); each one-year decrease in age at menarche was associated with a 9% increase (95% CI: 4%-14%) in odds of physical frailty. Age at menopause was also inversely associated with the likelihood of physical frailty (Ptrend = 0.009); every one-year decrease in age at menopause was associated with 2% (0%-4%) increased odds. In the assessment of frailty, younger ages at menarche and menopause were associated with greater likelihood of being in the slowest quintile for timed up-and-go and weakest quintile for handgrip strength. Conversely, duration of reproductive period, parity, and use of oral contraceptives or hormone replacement therapy were not significantly associated with the likelihood of physical frailty.
CONCLUSIONS: In our population-based cohort of Chinese women, younger ages at menarche and menopause were associated with higher likelihood of physical frailty in later life.
OBJECTIVE: Our study aimed to investigate the associations between 1) age at menarche, 2) age at natural menopause, 3) duration of reproductive period, 4) number of children, 5) use of oral contraceptives (OCP), and 6) use of hormone replacement therapy (HRT) with the risk of physical frailty in late life.
METHODS: We used data from 5934 women of the Singapore Chinese Health Study who experienced natural menopause, and participated in the third follow-up interviews when physical frailty was assessed. Logistic regression was used to evaluate association of reproductive factors evaluated during baseline and prior follow-up interviews with physical frailty at follow-up 3.
METHODS: Community-dwelling Chinese women living in Singapore. Participants had a mean age of 52.6 years at baseline (1993-1998), and a mean age of 72.8 years during the third follow-up (2014-2017).
METHODS: Sociodemographic characteristics, level of education, smoking history, physical activity, and history of physician-diagnosed comorbidities were collected. Participants\' weight and height were self-reported. We used a modified Cardiovascular Health Study phenotype to assess physical frailty.
RESULTS: Age at menarche was inversely associated with the likelihood of physical frailty (Ptrend = 0.001); each one-year decrease in age at menarche was associated with a 9% increase (95% CI: 4%-14%) in odds of physical frailty. Age at menopause was also inversely associated with the likelihood of physical frailty (Ptrend = 0.009); every one-year decrease in age at menopause was associated with 2% (0%-4%) increased odds. In the assessment of frailty, younger ages at menarche and menopause were associated with greater likelihood of being in the slowest quintile for timed up-and-go and weakest quintile for handgrip strength. Conversely, duration of reproductive period, parity, and use of oral contraceptives or hormone replacement therapy were not significantly associated with the likelihood of physical frailty.
CONCLUSIONS: In our population-based cohort of Chinese women, younger ages at menarche and menopause were associated with higher likelihood of physical frailty in later life.
摘要：
方法：尽管绝经年龄与晚年身体虚弱的风险增加有关，对其他生殖因素知之甚少。
目的：我们的研究旨在调查1）初潮年龄之间的关系，2）自然绝经年龄，3）生育期的持续时间，4）儿童人数，5）使用口服避孕药（OCP），和6）使用激素替代疗法（HRT），有晚年身体虚弱的风险。
方法：我们使用了新加坡华人健康研究的5934名自然更年期女性的数据，并在评估身体虚弱时参加了第三次随访访谈。使用Logistic回归评估在基线和先前随访访谈期间评估的生殖因素与随访3时的身体虚弱的关联。
方法：居住在新加坡的社区中国妇女。参与者在基线（1993-1998）时的平均年龄为52.6岁，在第三次随访期间(2014-2017年),平均年龄为72.8岁.
方法：社会人口统计学特征，教育水平,吸烟史,身体活动,并收集医师诊断的合并症病史.参与者的体重和身高是自我报告的。我们使用改良的心血管健康研究表型来评估身体虚弱。
结果：初潮年龄与体弱的可能性呈负相关（Ptrend=0.001）；初潮年龄每减少1年，体弱的几率增加9%（95%CI：4%-14%）。绝经年龄也与身体虚弱的可能性呈负相关（Ptrend=0.009）；绝经年龄每减少一年，几率增加2％（0％-4％）。在评估脆弱时，初潮和更年期的年龄较小，对于定时起跑和握力处于最慢的五分之一的可能性更大，对于握力处于最弱的五分之一的可能性更大。相反，生育期的持续时间，奇偶校验，口服避孕药或激素替代疗法的使用与身体虚弱的可能性无显著相关.
结论：在我们以人群为基础的中国女性队列中，初潮和绝经期年龄较小,晚年体弱的可能性较高.
目的：我们的研究旨在调查1）初潮年龄之间的关系，2）自然绝经年龄，3）生育期的持续时间，4）儿童人数，5）使用口服避孕药（OCP），和6）使用激素替代疗法（HRT），有晚年身体虚弱的风险。
方法：我们使用了新加坡华人健康研究的5934名自然更年期女性的数据，并在评估身体虚弱时参加了第三次随访访谈。使用Logistic回归评估在基线和先前随访访谈期间评估的生殖因素与随访3时的身体虚弱的关联。
方法：居住在新加坡的社区中国妇女。参与者在基线（1993-1998）时的平均年龄为52.6岁，在第三次随访期间(2014-2017年),平均年龄为72.8岁.
方法：社会人口统计学特征，教育水平,吸烟史,身体活动,并收集医师诊断的合并症病史.参与者的体重和身高是自我报告的。我们使用改良的心血管健康研究表型来评估身体虚弱。
结果：初潮年龄与体弱的可能性呈负相关（Ptrend=0.001）；初潮年龄每减少1年，体弱的几率增加9%（95%CI：4%-14%）。绝经年龄也与身体虚弱的可能性呈负相关（Ptrend=0.009）；绝经年龄每减少一年，几率增加2％（0％-4％）。在评估脆弱时，初潮和更年期的年龄较小，对于定时起跑和握力处于最慢的五分之一的可能性更大，对于握力处于最弱的五分之一的可能性更大。相反，生育期的持续时间，奇偶校验，口服避孕药或激素替代疗法的使用与身体虚弱的可能性无显著相关.
结论：在我们以人群为基础的中国女性队列中，初潮和绝经期年龄较小,晚年体弱的可能性较高.
