PDF(Pubmed)
Abstract：
This article reports the preparation of multifunctional magnetic nanocomposite hydrogels formed from wormlike micelles. Specifically, iron oxide nanoparticles were incorporated into a temperature responsive block copolymer, poly(glycerol monomethacrylate)-b-poly(2-hydroxypropyl methacrylate) (PGMA-b-PHPMA), and graphene oxide (GO) dispersion at a low temperature (∼2 °C) through high-speed mixing and returning the mixture to room temperature, resulting in the formation of nanocomposite gels. The optimal concentrations of iron oxide and GO enhanced the gel strength of the nanocomposite gels, which exhibited a strong magnetic response when a magnetic field was applied. These materials retained the thermoresponsiveness of the PGMA-PHPMA wormlike micelles allowing for a solid-to-liquid transition to occur when the temperature was reduced. The mechanical and rheological properties and performance of the nanocomposite gels were demonstrated to be adjustable, making them suitable for a wide range of potential applications. These nanocomposite worm gels were demonstrated to be relatively adhesive and to act as strain and temperature sensors, with the measured electrical resistance of the nanocomposite gels changing with applied strain and temperature sweeps. The nanocomposite gels were found to recover efficiently after the application of high shear with approximately 100% healing efficiency within seconds. Additionally, these nanocomposite worm gels were injectable, and the addition of GO and iron oxide nanomaterials seemed to have no significant adverse impact on the biocompatibility of the copolymer gels, making them suitable not only for 3D printing in nanocomposite engineering but also for potential utilization in various biomedical applications as an injectable magnetic responsive hydrogel.
摘要：
本文报道了由蠕虫状胶束形成的多功能磁性纳米复合水凝胶的制备。具体来说,将氧化铁纳米颗粒掺入温度响应性嵌段共聚物中，聚（单甲基丙烯酸甘油酯）-b-聚（2-羟丙酯）（PGMA-b-PHPMA），和氧化石墨烯（GO）分散在低温（〜2°C）通过高速混合并返回混合物到室温，导致纳米复合凝胶的形成。氧化铁和GO的最佳浓度增强了纳米复合凝胶的凝胶强度，当施加磁场时表现出强烈的磁响应。这些材料保留了PGMA-PHPMA蠕虫状胶束的热响应性,允许在温度降低时发生固液转变。纳米复合凝胶的机械和流变性能和性能被证明是可调节的，使它们适合广泛的潜在应用。这些纳米复合蠕虫凝胶被证明是相对粘合的，并作为应变和温度传感器，纳米复合材料凝胶的测量电阻随施加的应变和温度扫描而变化。发现纳米复合凝胶在施加高剪切后有效恢复,在数秒内具有约100%的愈合效率。此外,这些纳米复合蠕虫凝胶是可注射的，GO和氧化铁纳米材料的加入似乎对共聚物凝胶的生物相容性没有显著的不利影响,使它们不仅适用于纳米复合材料工程中的3D打印，而且适用于作为可注射磁响应水凝胶的各种生物医学应用。
